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Molecules 2015, 20(6), 11617-11631; doi:10.3390/molecules200611617

Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions

1
Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, UMR 6226 CNRS, 35042 Rennes Cedex, France
2
LSOA—Laboratoire de Synthèse Organique Appliquée, Department of chemistry, Oran 1 University, 1524 Oran, Algeria
3
Villapharma Research, Parque Tecnologico de Fuente Alamo, E-30320 Murcia, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Marilena Radoiu, Jean Jacques Vanden Eynde and Annie Mayence
Received: 28 May 2015 / Revised: 14 June 2015 / Accepted: 15 June 2015 / Published: 23 June 2015
(This article belongs to the Special Issue Microwave-Assisted Organic Synthesis)
View Full-Text   |   Download PDF [794 KB, uploaded 23 June 2015]   |  

Abstract

We here disclosed a new protocol for the condensation of acetophenone derivatives and active methylene compounds with aldehydes in the presence of boric acid under microwave conditions. Implementation of the reaction is simple, healthy and environmentally friendly owing to the use of a non-toxic catalyst coupled to a solvent-free procedure. A large variety of known or novel compounds have thus been prepared, including with substrates bearing acid or base-sensitive functional groups. View Full-Text
Keywords: condensation reaction; boric acid; catalysis; solvent-free; microwave condensation reaction; boric acid; catalysis; solvent-free; microwave
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Brun, E.; Safer, A.; Carreaux, F.; Bourahla, K.; L'helgoua'ch, J.-M.; Bazureau, J.-P.; Villalgordo, J.M. Microwave-Assisted Condensation Reactions of Acetophenone Derivatives and Activated Methylene Compounds with Aldehydes Catalyzed by Boric Acid under Solvent-Free Conditions. Molecules 2015, 20, 11617-11631.

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