Next Article in Journal
Triel Bonds, π-Hole-π-Electrons Interactions in Complexes of Boron and Aluminium Trihalides and Trihydrides with Acetylene and Ethylene
Previous Article in Journal
Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(6), 11272-11296; doi:10.3390/molecules200611272

Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity

1
Institute of General Food Chemistry, Łódź University of Technology, Stefanowskiego St. 4/10, 90-924 Łódź, Poland
2
Environmental Biology Department, Medical University of Łódź, Żeligowskiego St. 7/9, 90-752 Łódź, Poland
3
Institute of Technical Biochemistry, Łódź University of Technology, Stefanowskiego St. 4/10, 90-924 Łódź, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 30 April 2015 / Revised: 12 June 2015 / Accepted: 15 June 2015 / Published: 18 June 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [2806 KB, uploaded 18 June 2015]   |  

Abstract

By implementing a common and industrially used method, 30 compounds which are structurally related to geranyl acetone, nerolidol, farnesal, farnesol and farnesyl acetate were obtained. Their antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii bacteria was investigated. Pharmacophore models were proposed based on the obtained results and 3D QSAR modelling. Cytotoxic effects against mainly human immortalised and normal cell lines of different origin (malignant melanoma MeWo, colorectal adenocarcinoma HT29, promyelocytic leukemia HL60, gingival fibroblasts HFIG, skin keratinocytes HaCaT and rat small intestine epithelium IEC6) were examined. The odour descriptions of newly synthesised compounds are given. View Full-Text
Keywords: terpenoids; geranyl acetone; nerolidol; farnesol; farnesyl acetate; structurally related compound; antimicrobial activity; cytotoxicity terpenoids; geranyl acetone; nerolidol; farnesol; farnesyl acetate; structurally related compound; antimicrobial activity; cytotoxicity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Bonikowski, R.; Świtakowska, P.; Sienkiewicz, M.; Zakłos-Szyda, M. Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity. Molecules 2015, 20, 11272-11296.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top