Next Article in Journal
Selected Compounds Structurally Related to Acyclic Sesquiterpenoids and Their Antibacterial and Cytotoxic Activity
Next Article in Special Issue
Tilting Plant Metabolism for Improved Metabolite Biosynthesis and Enhanced Human Benefit
Previous Article in Journal
Understanding the Mechanism of Action of Triazine-Phosphonate Derivatives as Flame Retardants for Cotton Fabric
Previous Article in Special Issue
Essential Oil from Berries of Lebanese Juniperus excelsa M. Bieb Displays Similar Antibacterial Activity to Chlorhexidine but Higher Cytocompatibility with Human Oral Primary Cells
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(6), 11257-11271; doi:10.3390/molecules200611257

Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.

1
Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
2
Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
4
State Scientifically-Experimental and Production Organization, Academy of Sciences of the Republic of Tajikistan, Dushanbe 734063, Tajikistan
5
Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, 100170 Tashkent, Uzbekistan
6
Department of Chemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
*
Author to whom correspondence should be addressed.
Academic Editor: Marcello Iriti
Received: 17 May 2015 / Revised: 12 June 2015 / Accepted: 16 June 2015 / Published: 18 June 2015
View Full-Text   |   Download PDF [738 KB, uploaded 18 June 2015]   |  

Abstract

Phytochemical investigations of ethyl acetate-soluble part of the aerial part of Hypericum scabrum L. delivered eight pure phenolic compounds 18. The pure compounds were identified through physico-chemical, NMR (1D, 2D) and mass spectrometric studies as: 3-8′′-bisapigenin (1), quercetin (2), quercetin-3-O-α-l-arabinofuranoside (3), quercetin-3-O-α-l-rhamnoside (4), quercetin-3-O-β-d-glucopyranoside (5), quercetin-3-O-β-d-galactopyranoside (6), (−)-epicatechin (7), (+)-catechin (8). Total polyphenolic compounds and total flavonoids contents were determined in the extract as 0.107 mg∙mg−1 and 0.023 mg∙mg−1 of the dried extract, respectively. Antioxidant activity using DPPH free radical scavenging assay delivered very strong activity for compounds 2 and 5, 6 and crude extract 10. Protein tyrosine phosphatase 1B (PTP-1B) inhibition experiment of isolated compounds and crude extracts resulted in significant inhibition activity for samples 2, 7a, 8a, 11 and 12 with IC50 values ranging from 1.57 to 2.91 µM. Antimicrobial activity of the pure compounds and extracts produced average results against Staphylococcus aureus, Escherichia coli and Candida albicans strains. From our literature survey, it appears that all pure compounds except 2 were isolated and reported for the first time in H. scabrum. View Full-Text
Keywords: Hypericum scabrum L.; ethylacetate fraction; column chromatography; NMR; ESI-MS; antidiabetic activity; antioxidant activity; antimicrobial activity Hypericum scabrum L.; ethylacetate fraction; column chromatography; NMR; ESI-MS; antidiabetic activity; antioxidant activity; antimicrobial activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Jiang, L.; Numonov, S.; Bobakulov, K.; Qureshi, M.N.; Zhao, H.; Aisa, H.A. Phytochemical Profiling and Evaluation of Pharmacological Activities of Hypericum scabrum L.. Molecules 2015, 20, 11257-11271.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top