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Molecules 2015, 20(6), 10793-10799; doi:10.3390/molecules200610793

Metabolites Produced by the Endophytic Fungus Aspergillus fumigatus from the Stem of Erythrophloeum fordii Oliv.

1
Jiamusi College, Heilongjiang University of Chinese Medicine, Jiamusi 154007, China
2
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 May 2015 / Revised: 26 May 2015 / Accepted: 26 May 2015 / Published: 11 June 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [873 KB, uploaded 11 June 2015]   |  

Abstract

A new diketopiperazine alkaloid named spirotryprostatin K (1), and five known alkaloids, spiro[5H,10H-dipyrrolo[1,2-a:1′,2′-d]pyrazine-2(3H),2′-[2H]-indole]-3′,5,10(1′H) trione (2), 6-methoxyspirotryprostatin B (3), pseurotin A (4), N-β-acetyltryptamine (5), and lumichrome (6) were isolated from the endophytic fungus Aspergillus fumigatus. The structure and the absolute configuration of spirotryprostatin K were established by extensive spectroscopic analyses, acid hydrolysis and ECD calculations. Pseurotin A exhibited indirect anti-inflammatory activity by suppressing the lipopolysaccharide-induced proinflammatory factors in BV2 microglial cells, with an IC50 of 5.20 µM. View Full-Text
Keywords: endophytic fungus; Aspergillus fumigatus; Erythrophloeum fordii Oliv. endophytic fungus; Aspergillus fumigatus; Erythrophloeum fordii Oliv.
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Shi, Y.-S.; Zhang, Y.; Chen, X.-Z.; Zhang, N.; Liu, Y.-B. Metabolites Produced by the Endophytic Fungus Aspergillus fumigatus from the Stem of Erythrophloeum fordii Oliv.. Molecules 2015, 20, 10793-10799.

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