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Molecules 2015, 20(6), 10800-10821; doi:10.3390/molecules200610800

Progress in Studies on Rutaecarpine. II.—Synthesis and Structure-Biological Activity Relationships

College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea
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Academic Editor: Jean Jacques Vanden Eynde
Received: 14 May 2015 / Revised: 27 May 2015 / Accepted: 1 June 2015 / Published: 11 June 2015
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Abstract

Rutaecarpine is a pentacyclic indolopyridoquinazolinone alkaloid found in Evodia rutaecarpa and other related herbs. It has a variety of intriguing biological properties, which continue to attract the academic and industrial interest. Studies on rutaecarpine have included isolation from new natural sources, development of new synthetic methods for its total synthesis, the discovery of new biological activities, metabolism, toxicology, and establishment of analytical methods for determining rutaecarpine content. The present review focuses on the synthesis, biological activities, and structure-activity relationships of rutaecarpine derivatives, with respect to their antiplatelet, vasodilatory, cytotoxic, and anticholinesterase activities. View Full-Text
Keywords: alkaloid; rutaecarpine; antiplatelet activity; vasodilatory activity; anticancer activity; anti-cholinesterase activity; anti-obesity activity alkaloid; rutaecarpine; antiplatelet activity; vasodilatory activity; anticancer activity; anti-cholinesterase activity; anti-obesity activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Son, J.-K.; Chang, H.W.; Jahng, Y. Progress in Studies on Rutaecarpine. II.—Synthesis and Structure-Biological Activity Relationships. Molecules 2015, 20, 10800-10821.

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