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Molecules 2015, 20(6), 10487-10495; doi:10.3390/molecules200610487

Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides

Department of Chemistry and Biochemistry, the University of Southern Mississippi, 118 College Drive #5043, Hattiesburg, MS 39406, USA
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 17 May 2015 / Revised: 3 June 2015 / Accepted: 4 June 2015 / Published: 8 June 2015
(This article belongs to the Section Molecular Diversity)
View Full-Text   |   Download PDF [781 KB, uploaded 8 June 2015]   |  


Oxidized l-glutathione was esterified to the tetra methyl ester using thionyl chloride in methanol solvent. Other alcohols were tested and the reaction progress was monitored via ESI-MS. This procedure proved to be compatible with other small peptides not containing serine and cysteine residues. In contrast to previously reported methods this procedure provided convenient access to esterified peptides requiring no purification, extended reaction times, or complicated reaction setups. View Full-Text
Keywords: esterification; peptide esterification; amino acids; carboxylic acids; esters esterification; peptide esterification; amino acids; carboxylic acids; esters

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Vogel, E.R.; Jackson, W.; Masterson, D.S. Efficient Esterification of Oxidized l-Glutathione and Other Small Peptides. Molecules 2015, 20, 10487-10495.

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