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Molecules 2015, 20(6), 10468-10486; doi:10.3390/molecules200610468

Synthesis, Characterization, Antimicrobial Screening and Free-Radical Scavenging Activity of Some Novel Substituted Pyrazoles

Department of Chemistry, Faculty of Education, Alexandria University, Alexandria 21526, Egypt
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Author to whom correspondence should be addressed.
Academic Editor: Philippe Belmont
Received: 26 April 2015 / Revised: 1 June 2015 / Accepted: 1 June 2015 / Published: 8 June 2015
(This article belongs to the Collection Heterocyclic Compounds)
View Full-Text   |   Download PDF [771 KB, uploaded 8 June 2015]   |  

Abstract

The present work deals with the synthesis of acetoxysulfonamide pyrazole derivatives, substituted 4,5-dihydropyrazole-1-carbothioamide and 4,5-dihydropyrazole-1-isonicotinoyl derivatives starting from substituted vanillin chalcones. Acetoxysulfonamide pyrazole derivatives were prepared from the reaction of chalcones with p-sulfamylphenylhydrazine followed by treatment with acetic anhydride. At the same time 4,5-dihydropyrazole-1-carbothioamide and 4,5-dihydropyrazole-1-isonicotinoyl derivatives were prepared from the reaction of chalcones with either thiosemicarbazide or isonicotinic acid hydrazide, respectively. The synthesized compounds were structurally characterized on the basis of IR, 1H-NMR, 13C-NMR spectral data and microanalyses. All of the newly isolated compounds were tested for their antimicrobial activities. The antimicrobial screening using the agar well-diffusion method revealed that the chloro derivatives are the most active ones. Moreover, the antioxidant and anti-inflammatory activity of these chloro derivatives are also studied using the DPPH radical scavenging and NO radical scavenging methods, respectively. View Full-Text
Keywords: chalcones; sulfonamide pyrazole; isonicotinic acid hydrazide; antimicrobial activity; antioxidant; anti-inflammatory chalcones; sulfonamide pyrazole; isonicotinic acid hydrazide; antimicrobial activity; antioxidant; anti-inflammatory
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Hamada, N.M.M.; Abdo, N.Y.M. Synthesis, Characterization, Antimicrobial Screening and Free-Radical Scavenging Activity of Some Novel Substituted Pyrazoles. Molecules 2015, 20, 10468-10486.

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