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Molecules 2015, 20(5), 8988-8996; doi:10.3390/molecules20058988

Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells

1
LINC Project Group, Daejeon University, Daejeon 300-716, Korea
2
Department of Chemistry, Mokwon University, Daejeon 302-729, Korea
3
Soram Korean Medicine Hospital, M-Tower, Gangnam-Gu, Seoul 135-879, Korea
4
Soram Bio-Medicine Research Institute (SBRI), Soram Korean Medicine Hospital, M-Tower, Gangnam-Gu, Seoul 135-879, Korea
5
Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yeongudanjiro, Ochang, Cheongwon, Chungbuk 363-883, Korea
6
Hyehwa-Liberal Arts College, Daejeon University, Daejeon 300-716, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 2 April 2015 / Revised: 2 May 2015 / Accepted: 13 May 2015 / Published: 19 May 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [1074 KB, uploaded 19 May 2015]   |  

Abstract

Endoplasmic reticulum (ER) stress is linked with development and maintenance of cancer, and serves as a therapeutic target for treatment of cancer. Verrucarin A, isolated from the broth of Fusarium sp. F060190, showed potential inhibitory activity on tunicamycin-induced ER stress in FaO rat liver cells. In addition, the compound decreased tunicamycin-induced GRP78 promoter activity in a dose dependent manner without inducing significant inhibition of luciferase activity and cell growth for 6 and 12 h. Moreover, the compound decreased the expression of GRP78, CHOP, XBP-1, and suppressed XBP-1, and reduced phosphorylation of IRE1α in FaO rat liver cells. This evidence suggests for the first time that verrucarin A inhibited tunicamycin-induced ER stress in FaO rat liver cells. View Full-Text
Keywords: verrucarin A; Fusarium sp. F060190; tunicamycin; ER stress; FaO rat liver cells verrucarin A; Fusarium sp. F060190; tunicamycin; ER stress; FaO rat liver cells
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bae, E.Y.; Lee, S.W.; Seong, S.; Cho, W.; Ahn, J.S.; Cho, H.-S. Inhibitory Effects of Verrucarin A on Tunicamycin-Induced ER Stress in FaO Rat Liver Cells. Molecules 2015, 20, 8988-8996.

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