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Molecules 2015, 20(4), 6970-6977; doi:10.3390/molecules20046970

Alkylamides of Acmella oleracea

1
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung 807, Taiwan
3
School of Nutrition, College of Health Care and Management, Chung Shan Medical University, Taichung 40201, Taiwan
4
Chinese Herbal Medicine Research Center, China Medical University, Taichung 404, Taiwan
5
Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 926, Taiwan
6
Translational Research Center and Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
7
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
8
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
9
Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan
10
Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
11
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
12
Research Center for Natural Product & Drug Development, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 February 2015 / Revised: 25 March 2015 / Accepted: 8 April 2015 / Published: 16 April 2015
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [800 KB, uploaded 16 April 2015]   |  

Abstract

Phytochemical investigation of the flowers of Acmella oleracea had resulted in the isolation of one new alkylamide, (2E,5Z)-N-isobutylundeca-2,5-diene-8,10-diynamide (1), together with four known analogues (2-5). The structures of these compounds were determined by the interpretation of spectroscopic methods, especially NMR technologies (COSY, HSQC, HMBC, and NOESY). In addition, a convenient method for concentrating the alkylamide-rich fraction and analyzing fingerprint profile of A. oleracea was established. View Full-Text
Keywords: Acmella oleracea; alkylamide; quality control assessment Acmella oleracea; alkylamide; quality control assessment
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MDPI and ACS Style

Cheng, Y.-B.; Liu, R.H.; Ho, M.-C.; Wu, T.-Y.; Chen, C.-Y.; Lo, I.-W.; Hou, M.-F.; Yuan, S.-S.; Wu, Y.-C.; Chang, F.-R. Alkylamides of Acmella oleracea. Molecules 2015, 20, 6970-6977.

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