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Correction: Chigrinova, M., et al. Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling. Molecules 2015, 20, 6959-6969
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Correction published on 7 May 2015, see Molecules 2015, 20(5), 8303.

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Molecules 2015, 20(4), 6959-6969; doi:10.3390/molecules20046959

Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling

1
Life Sciences Division, National Research Council of Canada, Ottawa, ON K1A 0R6, Canada
2
Department of Chemistry, University of Ottawa, Ottawa, ON K1N 6N5, Canada
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: José Marco-Contelles
Received: 30 March 2015 / Revised: 12 April 2015 / Accepted: 13 April 2015 / Published: 16 April 2015
(This article belongs to the Special Issue Recent Developments of the Kinugasa Reaction)
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Abstract

The Kinugasa reaction has become an efficient method for the direct synthesis of β-lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with micelle-promoted [3+2] cycloadditions followed by rearrangement furnishing high yields of β-lactams. The high yields of stable products under aqueous conditions render the modified Kinugasa reaction amenable to metabolic labelling and bioorthogonal applications. Herein, the development of methods for use of the Kinugasa reaction in aqueous media is reviewed, with emphasis on its potential use as a bioorthogonal coupling strategy. View Full-Text
Keywords: nitrones; aqueous Kinugasa reaction; β-lactams; bioorthogonal; metabolic labelling nitrones; aqueous Kinugasa reaction; β-lactams; bioorthogonal; metabolic labelling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chigrinova, M.; MacKenzie, D.A.; Sherratt, A.R.; Cheung, L.L.W.; Pezacki, J.P. Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling. Molecules 2015, 20, 6959-6969.

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