Next Article in Journal
Silver Nanopartical over AuFON Substrate for Enhanced Raman Readout and Their Application in Pesticide Monitoring
Next Article in Special Issue
Insights into the Antimicrobial Properties of Hepcidins: Advantages and Drawbacks as Potential Therapeutic Agents
Previous Article in Journal
Hepatoprotective Triterpene Saponins from the Roots of Glycyrrhiza inflata
Previous Article in Special Issue
Bactericidal Effect of Extracts and Metabolites of Robinia pseudoacacia L. on Streptococcus mutans and Porphyromonas gingivalis Causing Dental Plaque and Periodontal Inflammatory Diseases
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(4), 6284-6298; doi:10.3390/molecules20046284

Synthesis, Photophysical Characterization, and Photoinduced Antibacterial Activity of Methylene Blue-loaded Amino- and Mannose-Targeted Mesoporous Silica Nanoparticles

Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017 Barcelona, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 27 February 2015 / Revised: 29 March 2015 / Accepted: 2 April 2015 / Published: 9 April 2015
View Full-Text   |   Download PDF [1211 KB, uploaded 9 April 2015]   |  

Abstract

Over the last 20 years, the number of pathogenic multi-resistant microorganisms has grown steadily, which has stimulated the search for new strategies to combat antimicrobial resistance. Antimicrobial photodynamic therapy (aPDT), also called photodynamic inactivation, is emerging as a promising alternative to treatments based on conventional antibiotics. We have explored the effectiveness of methylene blue-loaded targeted mesoporous silica nanoparticles (MSNP) in the photodynamic inactivation of two Gram negative bacteria, namely Escherichia coli and Pseudomonas aeruginosa. For E. coli, nanoparticle association clearly reduced the dark toxicity of MB while preserving its photoinactivation activity. For P. aeruginosa, a remarkable difference was observed between amino- and mannose-decorated nanoparticles. The details of singlet oxygen production in the nanoparticles have been characterized, revealing the presence of two populations of this cytotoxic species. Strong quenching of singlet oxygen within the nanoparticles is observed. View Full-Text
Keywords: antimicrobial photodynamic therapy (aPDT); singlet oxygen (1O2); mesoporous silica nanoparticle (MSNP); methylene blue; drug delivery system; mannose; E. coli; P. aeruginosa antimicrobial photodynamic therapy (aPDT); singlet oxygen (1O2); mesoporous silica nanoparticle (MSNP); methylene blue; drug delivery system; mannose; E. coli; P. aeruginosa
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Planas, O.; Bresolí-Obach, R.; Nos, J.; Gallavardin, T.; Ruiz-González, R.; Agut, M.; Nonell, S. Synthesis, Photophysical Characterization, and Photoinduced Antibacterial Activity of Methylene Blue-loaded Amino- and Mannose-Targeted Mesoporous Silica Nanoparticles. Molecules 2015, 20, 6284-6298.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top