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Molecules 2015, 20(4), 6273-6283; doi:10.3390/molecules20046273

Hepatoprotective Triterpene Saponins from the Roots of Glycyrrhiza inflata

1
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
2
Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing 210023, China
3
Translational Medicine Research Center of Nanjing University of Chinese Medicine, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 4 March 2015 / Revised: 1 April 2015 / Accepted: 2 April 2015 / Published: 9 April 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [786 KB, uploaded 9 April 2015]   |  

Abstract

Two novel oleanane-type triterpene saponins, licorice-saponin P2 (1) and licorice-saponin Q2 (3), together with nine known compounds 2, 411, have been isolated from the water extract of the roots of Glycyrrhiza inflata. The structures of these compounds were elucidated on the basis of spectroscopic analysis, including 2D-NMR experiments (1H–1H COSY, HSQC, HMBC and ROESY). In in vitro assays, compounds 24, 6 and 11 showed significant hepatoprotective activities by lowering the ALT and AST levels in primary rat hepatocytes injured by D-galactosamine (D-GalN). In addition, compounds 24, 6, 7 and 11 were found to inhibit the activity of PLA2 with IC50 values of 6.9 μM, 3.6 μM, 16.9 μM, 27.1 μM, 32.2 μM and 9.3 μM, respectively, which might be involved in the regulation of the hepatoprotective activities observed. View Full-Text
Keywords: Glycyrrhiza inflate; genus Glycyrrhiza; triterpene saponin; hepatoprotective; phospholipase A2 Glycyrrhiza inflate; genus Glycyrrhiza; triterpene saponin; hepatoprotective; phospholipase A2
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zheng, Y.-F.; Wei, J.-H.; Fang, S.-Q.; Tang, Y.-P.; Cheng, H.-B.; Wang, T.-L.; Li, C.-Y.; Peng, G.-P. Hepatoprotective Triterpene Saponins from the Roots of Glycyrrhiza inflata . Molecules 2015, 20, 6273-6283.

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