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Molecules 2015, 20(3), 5074-5084; doi:10.3390/molecules20035074

Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives

1
Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea
2
Department of Chemistry, Yonsei University, Seodaemun-gu, Seoul 120-749, Korea
3
Department of Chemistry, College of Natural Sciences, Sangmyung University, Seoul 110-743, Korea
4
Department of Biological Chemistry, University of Science and Technology, Youseong-gu, Daejeon 305-350, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 27 January 2015 / Revised: 12 March 2015 / Accepted: 13 March 2015 / Published: 19 March 2015
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [707 KB, uploaded 19 March 2015]   |  

Abstract

A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases. View Full-Text
Keywords: dihydropyridothienopyrimidin-4,9-dione; pyridothienopyrimidine; successive ring formation dihydropyridothienopyrimidin-4,9-dione; pyridothienopyrimidine; successive ring formation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kim, Y.; Kim, M.; Park, M.; Tae, J.; Baek, D.-J.; Park, K.D.; Choo, H. Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives. Molecules 2015, 20, 5074-5084.

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