Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives
AbstractA novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases. View Full-Text
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Kim, Y.; Kim, M.; Park, M.; Tae, J.; Baek, D.-J.; Park, K.D.; Choo, H. Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives. Molecules 2015, 20, 5074-5084.
Kim Y, Kim M, Park M, Tae J, Baek D-J, Park KD, Choo H. Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives. Molecules. 2015; 20(3):5074-5084.Chicago/Turabian Style
Kim, Youngjae; Kim, Minjoo; Park, Mooseong; Tae, Jinsung; Baek, Du-Jong; Park, Ki D.; Choo, Hyunah. 2015. "Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives." Molecules 20, no. 3: 5074-5084.