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Molecules 2015, 20(3), 3811-3820; doi:10.3390/molecules20033811

An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions

1
Key Laboratory of Petroleum and Gas Fine Chemicals of Ministry of Education, School of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China
2
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
3
Physics and Chemistry Detecting Center, Xinjiang University, Urumqi 830046, China
*
Author to whom correspondence should be addressed.
Academic Editor: Kei Saito
Received: 24 November 2014 / Revised: 15 February 2015 / Accepted: 17 February 2015 / Published: 26 February 2015
(This article belongs to the Special Issue Frontier in Green Chemistry Approaches)
View Full-Text   |   Download PDF [412 KB, uploaded 26 February 2015]   |  

Abstract

We report here an efficient and green method for Biginelli condensation reaction of aldehydes, β-ketoesters and urea or thiourea catalyzed by Brønsted acidic ionic liquid [Btto][p-TSA] under solvent-free conditions. Compared to the classical Biginelli reaction conditions, the present method has the advantages of giving good yields, short reaction times, near room temperature conditions and the avoidance of the use of organic solvents and metal catalyst. View Full-Text
Keywords: [Btto][p-TSA]; Biginelli reaction; dihydropyrimidinones; solvent-free [Btto][p-TSA]; Biginelli reaction; dihydropyrimidinones; solvent-free
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhang, Y.; Wang, B.; Zhang, X.; Huang, J.; Liu, C. An Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones Catalyzed by a Novel Brønsted Acidic Ionic Liquid under Solvent-Free Conditions. Molecules 2015, 20, 3811-3820.

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