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Molecules 2015, 20(2), 2668-2684; doi:10.3390/molecules20022668

Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents

1
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey
2
Graduate School of Health Sciences, Anadolu University, 26470 Eskişehir, Turkey
3
Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 January 2015 / Revised: 28 January 2015 / Accepted: 30 January 2015 / Published: 4 February 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [819 KB, uploaded 4 February 2015]   |  

Abstract

In an effort to develop potent antidepressant agents, new pyrazoline derivatives 2as were synthesized and evaluated for their antidepressant-like activity by tail suspension test (TST) and modified forced swimming test (MFST). The effects of the compounds on spontaneous locomotor activity were also investigated using an activity cage apparatus. Among these derivatives, compounds 2b, 2d, 2f, 2o, and 2r decreased both horizontal and vertical activity number of the mice. On the other hand, compounds 2a, 2h, 2j, 2k, 2l, 2m, and 2n, which did not induce any significant change in the locomotor activity, significantly shortened the immobility time of mice in TST and MFST, representing the presence of the antidepressant-like effect. Additionally, the same compounds increased the swimming time of mice in MFST without any change in climbing duration, similar to the reference drug fluoxetine (10 mg/kg). In the light of previous papers examining the effects of pyrazolines on central nervous system, this study, once more, pointed out remarkable antidepressant activity potential of pyrazoline derivatives. View Full-Text
Keywords: pyrazoline; antidepressant activity; tail suspension test; modified forced swimming test; activity cage pyrazoline; antidepressant activity; tail suspension test; modified forced swimming test; activity cage
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Özdemir, A.; Altıntop, M.D.; Kaplancıklı, Z.A.; Can, Ö.D.; Demir Özkay, Ü.; Turan-Zitouni, G. Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents. Molecules 2015, 20, 2668-2684.

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