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Molecules 2015, 20(2), 2165-2175; doi:10.3390/molecules20022165

New Lignans and Iridoid Glycosides from Dipsacus asper Wall

1
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
2
State Nationalities Affairs Commission and Department of Educational Key Lab of Minority Traditional Medicine, MINZU University of China, Beijing 10081, China
3
Beijing Institute of Microchemistry, Beijing 100091, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 7 January 2015 / Revised: 20 January 2015 / Accepted: 22 January 2015 / Published: 28 January 2015
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [788 KB, uploaded 28 January 2015]   |  

Abstract

Six new compounds, including four new lignans, dipsalignan A (1), B–D (35), and two new bis-iridoid glycoside dimmers, dipsanosides M (7) and N (8), together with two known compounds (2) and (6), have been isolated from the roots of Dipsacus asper Wall. Their structures were established on the basis of spectroscopic data (MS, 1D, 2D NMR, and CD) and chemical methods. All the isolated compounds were tested against human immunodeficiency virus-1 (HIV-1) integrase inhibition activities, and only compounds 1, 2, 7, and 8 displayed weak activities. View Full-Text
Keywords: Dipsacus asper Wall; lignans; bis-iridoid glycoside Dipsacus asper Wall; lignans; bis-iridoid glycoside
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sun, X.; Ma, G.; Zhang, D.; Huang, W.; Ding, G.; Hu, H.; Tu, G.; Guo, B. New Lignans and Iridoid Glycosides from Dipsacus asper Wall. Molecules 2015, 20, 2165-2175.

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