Tyrosine Sulfation as a Protein Post-Translational Modification
AbstractIntegration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases. Protein tyrosine sulfation (PTS) is a common post-translational modification that was first reported in the literature fifty years ago. However, the significance of PTS under physiological conditions and its link to diseases have just begun to be appreciated in recent years. PTS is catalyzed by tyrosylprotein sulfotransferase (TPST) through transfer of an activated sulfate from 3'-phosphoadenosine-5'-phosphosulfate to tyrosine in a variety of proteins and peptides. Currently, only a small fraction of sulfated proteins is known and the understanding of the biological sulfation mechanisms is still in progress. In this review, we give an introductory and selective brief review of PTS and then summarize the basic biochemical information including the activity and the preparation of TPST, methods for the determination of PTS, and kinetics and reaction mechanism of TPST. This information is fundamental for the further exploration of the function of PTS that induces protein-protein interactions and the subsequent biochemical and physiological reactions. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Yang, Y.-S.; Wang, C.-C.; Chen, B.-H.; Hou, Y.-H.; Hung, K.-S.; Mao, Y.-C. Tyrosine Sulfation as a Protein Post-Translational Modification. Molecules 2015, 20, 2138-2164.
Yang Y-S, Wang C-C, Chen B-H, Hou Y-H, Hung K-S, Mao Y-C. Tyrosine Sulfation as a Protein Post-Translational Modification. Molecules. 2015; 20(2):2138-2164.Chicago/Turabian Style
Yang, Yuh-Shyong; Wang, Chen-Chu; Chen, Bo-Han; Hou, You-Hua; Hung, Kuo-Sheng; Mao, Yi-Chih. 2015. "Tyrosine Sulfation as a Protein Post-Translational Modification." Molecules 20, no. 2: 2138-2164.