Next Article in Journal
A Protein Isolate from Moringa oleifera Leaves Has Hypoglycemic and Antioxidant Effects in Alloxan-Induced Diabetic Mice
Previous Article in Journal
Novel Magnetic Cross-Linked Cellulase Aggregates with a Potential Application in Lignocellulosic Biomass Bioconversion
Previous Article in Special Issue
Tyrosine Sulfation as a Protein Post-Translational Modification
Article Menu
Issue 2 (February) cover image

Export Article

Open AccessReview
Molecules 2017, 22(2), 259; doi:10.3390/molecules22020259

The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites

Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-159, 04510 Mexico City, Mexico
*
Author to whom correspondence should be addressed.
Received: 31 October 2016 / Accepted: 3 February 2017 / Published: 10 February 2017
(This article belongs to the Special Issue Sulfur Atom: Element for Adaptation to an Oxidative Environment)
View Full-Text   |   Download PDF [4416 KB, uploaded 14 February 2017]   |  

Abstract

The use of oxygen as the final electron acceptor in aerobic organisms results in an improvement in the energy metabolism. However, as a byproduct of the aerobic metabolism, reactive oxygen species are produced, leaving to the potential risk of an oxidative stress. To contend with such harmful compounds, living organisms have evolved antioxidant strategies. In this sense, the thiol-dependent antioxidant defense systems play a central role. In all cases, cysteine constitutes the major building block on which such systems are constructed, being present in redox substrates such as glutathione, thioredoxin, and trypanothione, as well as at the catalytic site of a variety of reductases and peroxidases. In some cases, the related selenocysteine was incorporated at selected proteins. In invertebrate parasites, antioxidant systems have evolved in a diversity of both substrates and enzymes, representing a potential area in the design of anti-parasite strategies. The present review focus on the organization of the thiol-based antioxidant systems in invertebrate parasites. Differences between these taxa and its final mammal host is stressed. An understanding of the antioxidant defense mechanisms in this kind of parasites, as well as their interactions with the specific host is crucial in the design of drugs targeting these organisms. View Full-Text
Keywords: antioxidant systems; parasites; thiol-dependent peroxidase; disulfide reductase; redoxin; thiol; redox mechanisms antioxidant systems; parasites; thiol-dependent peroxidase; disulfide reductase; redoxin; thiol; redox mechanisms
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Guevara-Flores, A.; Martínez-González, J.J.; Rendón, J.L.; del Arenal, I.P. The Architecture of Thiol Antioxidant Systems among Invertebrate Parasites. Molecules 2017, 22, 259.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top