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Molecules 2015, 20(11), 20901-20911; doi:10.3390/molecules201119734

Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China
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Author to whom correspondence should be addressed.
Academic Editor: Jianbo Xiao
Received: 6 October 2015 / Revised: 8 November 2015 / Accepted: 16 November 2015 / Published: 23 November 2015
(This article belongs to the Section Natural Products)
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Abstract

Box-Behnken design (BBD), one of the most common response surface methodology (RSM) methods, was used to optimize the experimental conditions for ultrasound-assisted extraction of polysaccharides from Rhynchosia minima root (PRM). The antioxidant abilities and anticancer activity of purified polysaccharide fractions were also measured. The results showed that optimal extraction parameters were as follows: ultrasound exposure time, 21 min; ratio of water to material, 46 mL/g; ultrasound extraction temperature, 63 °C. Under these conditions, the maximum yield of PRM was 16.95% ± 0.07%. Furthermore, the main monosaccharides of purified fractions were Ara and Gal. PRM3 and PRM5 exhibited remarkable DPPH radical scavenging activities and reducing power in vitro. PRM3 showed strong inhibitory activities on the growth of MCF-7 cells in vitro. The above results indicate that polysaccharides from R. minima root have the potential to be developed as natural antioxidants and anticancer ingredients for the food and pharmaceutical industries. View Full-Text
Keywords: Rhynchosia minima root; polysaccharide; ultrasound-assisted extraction; antioxidant activity; anticancer activity Rhynchosia minima root; polysaccharide; ultrasound-assisted extraction; antioxidant activity; anticancer activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Jia, X.; Zhang, C.; Hu, J.; He, M.; Bao, J.; Wang, K.; Li, P.; Chen, M.; Wan, J.; Su, H.; Zhang, Q.; He, C. Ultrasound-Assisted Extraction, Antioxidant and Anticancer Activities of the Polysaccharides from Rhynchosia minima Root. Molecules 2015, 20, 20901-20911.

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