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Molecules 2015, 20(10), 17735-17746; doi:10.3390/molecules201017735

Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract

1
EA 921 SONAS, Université D'Angers, SFR QUASAV 4207, Campus du Végétal, 42, rue Georges Morel, Beaucouzé 49070, France
2
Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay, 1, av. de la Terrasse, Gif-sur-Yvette 91198, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 7 July 2015 / Revised: 25 August 2015 / Accepted: 17 September 2015 / Published: 25 September 2015
(This article belongs to the Special Issue Coumarins, Xanthones and Related Compounds)
View Full-Text   |   Download PDF [764 KB, uploaded 25 September 2015]   |  

Abstract

Through dereplication analysis, seven known Mammea coumarins were identified in a fraction obtained from Mammea neurophylla dichloromethane bark extract selected for its ability to prevent advanced glycation end-product (AGE) formation. Among them, a careful examination of the NMR dataset of pedilanthocoumarin B led to a structural revision. Inspection of LC-DAD-MSn chromatograms allowed us to predict the presence of four new compounds, which were further isolated. Using spectroscopic methods (1H-, 13C- and 2D-NMR, HRMS, UV), these compounds were identified as new benzoyl substituted 4-phenylcoumarins (iso-pedilanthocoumarin B and neurophyllol C) and 4-(1-acetoxypropyl)coumarins cyclo F (ochrocarpins H and I). View Full-Text
Keywords: 4-(1-acetoxypropyl)coumarins; benzoylcoumarins; Calophyllaceae; dereplication analysis; 4-phenylcoumarins 4-(1-acetoxypropyl)coumarins; benzoylcoumarins; Calophyllaceae; dereplication analysis; 4-phenylcoumarins
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dang, B.T.; Rouger, C.; Litaudon, M.; Richomme, P.; Séraphin, D.; Derbré, S. Identification of Minor Benzoylated 4-Phenylcoumarins from a Mammea neurophylla Bark Extract. Molecules 2015, 20, 17735-17746.

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