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Molecules 2015, 20(1), 519-541; doi:10.3390/molecules20010519

Insights into Animal and Plant Lectins with Antimicrobial Activities

1
SInova, Programa de Pós Graduação em Biotecnologia, Universidade Católica Dom Bosco, 79117-900 Campo Grande, MS, Brazil
2
Centro de Análises Proteômicas e Bioquímicas, Pós-Graduação em Ciências Genômicas e Biotecnologia, Universidade Católica de Brasília, 70790-100 Brasília, DF, Brazil
*
Author to whom correspondence should be addressed.
Academic Editor: Tzi Bun NG
Received: 7 November 2014 / Accepted: 22 December 2014 / Published: 5 January 2015
(This article belongs to the Special Issue Lectins)
View Full-Text   |   Download PDF [1730 KB, uploaded 5 January 2015]   |  

Abstract

Lectins are multivalent proteins with the ability to recognize and bind diverse carbohydrate structures. The glyco -binding and diverse molecular structures observed in these protein classes make them a large and heterogeneous group with a wide range of biological activities in microorganisms, animals and plants. Lectins from plants and animals are commonly used in direct defense against pathogens and in immune regulation. This review focuses on sources of animal and plant lectins, describing their functional classification and tridimensional structures, relating these properties with biotechnological purposes, including antimicrobial activities. In summary, this work focuses on structural-functional elucidation of diverse lectin groups, shedding some light on host-pathogen interactions; it also examines their emergence as biotechnological tools through gene manipulation and development of new drugs. View Full-Text
Keywords: lectin; carbohydrate; antimicrobial; animal defense; plant defense lectin; carbohydrate; antimicrobial; animal defense; plant defense
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dias, R.O.; Machado, L.S.; Migliolo, L.; Franco, O.L. Insights into Animal and Plant Lectins with Antimicrobial Activities. Molecules 2015, 20, 519-541.

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