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Molecules 2015, 20(1), 1293-1303; doi:10.3390/molecules20011293

Ginsenoside Rc Promotes Anti-Adipogenic Activity on 3T3-L1 Adipocytes by Down-Regulating C/EBPα and PPARγ

1
Department of Food and Nutrition, Kyunghee University, Seoul 130-701, Korea
2
Division of Strategic Food Research, Ginseng Research Center, Korea Food Research Institute, Seongnam 463-746, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 November 2014 / Accepted: 9 January 2015 / Published: 14 January 2015
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Panax ginseng and its major components, the ginsenosides, are widely used in oriental medicine for the prevention of various disorders. In the present study, the inhibitory activity of ginsenoside Rc on adipogenesis was investigated using the 3T3-L1 cell line. The results obtained showed that Rc reduced the proliferation and viability of 3T3-L1 preadipocytes in a dose-dependent manner. Treatment with Rc decreased the number of adipocytes and reduced lipid accumulation in maturing 3T3-L1 preadipocytes, demonstrating an inhibitory effect on lipogenesis. Moreover, it was found that Rc directly induced lipolysis in adipocytes and down-regulated the expression of major transcription factors of the adipogenesis pathway, such as PPARγ and C/EBPα. These findings indicate that Rc is capable of suppressing adipogenesis and therefore they seem to be natural bioactive factors effective in adipose tissue mass modulation. View Full-Text
Keywords: ginsenoside Rc; 3T3-L1; obesity ginsenoside Rc; 3T3-L1; obesity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yang, J.-W.; Kim, S.S. Ginsenoside Rc Promotes Anti-Adipogenic Activity on 3T3-L1 Adipocytes by Down-Regulating C/EBPα and PPARγ. Molecules 2015, 20, 1293-1303.

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