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Molecules 2015, 20(1), 1151-1160; doi:10.3390/molecules20011151

Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines

1
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, Vietnam
2
College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea
3
Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi 10000, Vietnam
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 5 December 2014 / Accepted: 6 January 2015 / Published: 12 January 2015
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Abstract

Nine new chromonylthiazolidine derivatives were successfully semi-synthesized from paeonol. All of the compounds, including starting materials, the intermediate compound and products, were evaluated for their cytotoxic effects toward eight human cancer cell lines. The synthesized chromonylthiazolidines displayed weak cytotoxic effects against the tested cancer cell lines, but selective cytotoxic effects were observed. Compounds 3a and 3b showed the most selective cytotoxic effects against human epidermoid carcinoma (IC50 44.1 ± 3.6 μg/mL) and breast cancer (IC50 32.8 ± 1.4 μg/mL) cell lines, respectively. The results suggest that chromoylthiazolidines are potential low-cost, and selective anticancer agents. View Full-Text
Keywords: anti-cancer agent; chromonylthiazolidine; Paeonia lactiflora; paeonol; selective cytotoxicity; semi-synthesis anti-cancer agent; chromonylthiazolidine; Paeonia lactiflora; paeonol; selective cytotoxicity; semi-synthesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Anh, H.L.T.; Cuc, N.T.; Tai, B.H.; Yen, P.H.; Nhiem, N.X.; Thao, D.T.; Nam, N.H.; Van Minh, C.; Van Kiem, P.; Kim, Y.H. Synthesis of Chromonylthiazolidines and Their Cytotoxicity to Human Cancer Cell Lines. Molecules 2015, 20, 1151-1160.

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