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Molecules 2015, 20(1), 1003-1013; doi:10.3390/molecules20011003

Neuroprotective and Neuroregenerative Effects of Nimodipine in a Model System of Neuronal Differentiation and Neurite Outgrowth

1
Institute for Physiological Chemistry, Martin-Luther University, Hollystr. 1, Halle (Saale) D-06114, Germany
2
Department of Neurosurgery, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Straße 40, Halle (Saale) D-06120, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 November 2014 / Accepted: 30 December 2014 / Published: 9 January 2015
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Nimodipine is a Ca2+-channel antagonist mainly used for the management of aneurysmal subarachnoid hemorrhage (aSAH) to prevent cerebral vasospasms. However, it is not clear if the better outcome of nimodipine-treated patients is mainly due to vasodilatation or whether other cellular neuroprotective or neuregenerative effects of nimodipine are involved. We analysed PC12 cells after different stress stimuli with or without nimodipine pretreatment. Cytotoxicity of 200 mM EtOH and osmotic stress (450 mosmol/L) was significantly reduced with nimodipine pretreatment, while nimodipine has no influence on the hypoxia-induced cytotoxicity in PC12 cells. The presence of nimodipine also increased the NGF-induced neurite outgrowth in PC12 cells. However, nimodipine alone was not able to induce neurite outgrowth in PC12 cells. These results support the idea that nimodipine has general neuroprotective or neuregenerative effect beside its role in vasodilatation and is maybe useful also in other clinical applications beside aSAH. View Full-Text
Keywords: Ca2+ channels; neuroprotection; neurite outgrowth; nimodipine Ca2+ channels; neuroprotection; neurite outgrowth; nimodipine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Bork, K.; Wurm, F.; Haller, H.; Strauss, C.; Scheller, C.; Gnanapragassam, V.S.; Horstkorte, R. Neuroprotective and Neuroregenerative Effects of Nimodipine in a Model System of Neuronal Differentiation and Neurite Outgrowth. Molecules 2015, 20, 1003-1013.

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