Next Article in Journal
Synthesis of New Quinoxalines Containing an Oxirane Ring by the TDAE Strategy and in Vitro Evaluation in Neuroblastoma Cell Lines
Previous Article in Journal
A Multi-Scale–Multi-Stable Model for the Rhodopsin Photocycle
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(9), 14979-14986; doi:10.3390/molecules190914979

Pharmacological Effects of “Jutsu” (Atractylodis rhizome and Atractylodis lanceae rhizome) on 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-Induced Head Twitch Response in Mice (I)

1
Kampo Research Laboratories, Kracie Pharma Ltd., Kanebo machi 3-1, Takaoka, Toyama 933-0856, Japan
2
School of Pharmacy, College of Pharmacy, Taipei Medical University, 250 Wu-Hsing Street, Taipei 110, Taiwan
*
Author to whom correspondence should be addressed.
Received: 17 July 2014 / Revised: 10 September 2014 / Accepted: 12 September 2014 / Published: 18 September 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [705 KB, uploaded 18 September 2014]   |  

Abstract

Hallucinations are a common non-motor symptom of Parkinson’s disease and various forms of dementias. Yokukansan and Yokukansankachimpihange have attracted attention due to their effectiveness in the treatment of hallucinations of dementia. To clarify which component in these formulas contribute to the effects, at first, we focused on their differences in compositions to examine the pharmacological effects on the selective 5-HT2A/2C agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced head-twitch response (HTR) in mice that has been used as animal hallucination model. Results indicated that water extract of Byaku-jutsu (Atractylodes japonica) showed a stronger inhibitory effect on DOI-induced HTR than that of So-jutsu (A. lancea) corresponding to their major constituents of atractylenolide III and β-eudesmol, and suggested that the major constituents should be active constituents contributing to the antihallucination effects of Byaku- and So-jutsu. Besides, the part B–C ring (butenolide) in atractylenolide III was found to be similar to the structure of serotonin and suggested that the B–C ring may partially play role in antagonistic activity against serotonin receptors. Thus, a novel, rational design of butenolide-related compounds may as potential lead compounds for new drug development. Analysis of the chemical components of Byaku- and So-jutsu and further study on their structure-activity relationships are currently in progress. View Full-Text
Keywords: hallucinations; Atractylodis rhizome (Byaku-jutsu); Atractylodis lanceae rhizome (So-jutsu); atractylenolide III; β-eudesmol; DOI-induced head-twitch hallucinations; Atractylodis rhizome (Byaku-jutsu); Atractylodis lanceae rhizome (So-jutsu); atractylenolide III; β-eudesmol; DOI-induced head-twitch
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Murayama, C.; Wang, C.-C.; Michihara, S.; Norimoto, H. Pharmacological Effects of “Jutsu” (Atractylodis rhizome and Atractylodis lanceae rhizome) on 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-Induced Head Twitch Response in Mice (I). Molecules 2014, 19, 14979-14986.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top