Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis
AbstractTuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is responsible for over 1.3 million deaths each year. The impractically long treatment schedules (generally 6–9 months) and unpleasant side effects of the current drugs often lead to poor patient compliance, which in turn has resulted in the emergence of multi-, extensively- and totally-drug resistant strains. The development of new classes of anti-tuberculosis drugs and new drug targets is of global importance, since attacking the bacterium using multiple strategies provides the best means to prevent resistance. This review presents an overview of the various strategies and compounds utilized to inhibit glutamine synthetase, a promising target for the development of drugs for TB therapy. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Mowbray, S.L.; Kathiravan, M.K.; Pandey, A.A.; Odell, L.R. Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis. Molecules 2014, 19, 13161-13176.
Mowbray SL, Kathiravan MK, Pandey AA, Odell LR. Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis. Molecules. 2014; 19(9):13161-13176.Chicago/Turabian Style
Mowbray, Sherry L.; Kathiravan, Muthu K.; Pandey, Abhishek A.; Odell, Luke R. 2014. "Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis." Molecules 19, no. 9: 13161-13176.