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Molecules 2014, 19(9), 13161-13176; doi:10.3390/molecules190913161

Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis

1
Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Biomedical Center, Box 596, SE-751 24 Uppsala, Sweden
2
Seven Hills College of Pharmacy, Venkatramapuram (Via) Tanapalli, 517561 Tirupati, India
3
Department of Pharmaceutical Chemistry, Sinhgad College of Pharmacy, Vadgaon (BK), 411041 Pune, India
4
Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Biomedical Center, Box 574, SE-751 23 Uppsala, Sweden
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 July 2014 / Revised: 12 August 2014 / Accepted: 18 August 2014 / Published: 26 August 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Globally, tuberculosis is second only to AIDS in mortality and the disease is responsible for over 1.3 million deaths each year. The impractically long treatment schedules (generally 6–9 months) and unpleasant side effects of the current drugs often lead to poor patient compliance, which in turn has resulted in the emergence of multi-, extensively- and totally-drug resistant strains. The development of new classes of anti-tuberculosis drugs and new drug targets is of global importance, since attacking the bacterium using multiple strategies provides the best means to prevent resistance. This review presents an overview of the various strategies and compounds utilized to inhibit glutamine synthetase, a promising target for the development of drugs for TB therapy. View Full-Text
Keywords: tuberculosis; glutamine synthetase; drug discovery; structure-activity relationship; Mycobacterium tuberculosis tuberculosis; glutamine synthetase; drug discovery; structure-activity relationship; Mycobacterium tuberculosis
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MDPI and ACS Style

Mowbray, S.L.; Kathiravan, M.K.; Pandey, A.A.; Odell, L.R. Inhibition of Glutamine Synthetase: A Potential Drug Target in Mycobacterium tuberculosis. Molecules 2014, 19, 13161-13176.

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