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Molecules 2014, 19(9), 13093-13103; doi:10.3390/molecules190913093

Microwave Assisted Convenient One-Pot Synthesis of Coumarin Derivatives via Pechmann Condensation Catalyzed by FeF3 under Solvent-Free Conditions and Antimicrobial Activities of the Products

Department of Chemistry, Faculty of Science, Islamic Azad University-Tonekabon Branch, Tonekabon 46841-61167, Iran
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Received: 30 June 2014 / Revised: 4 August 2014 / Accepted: 11 August 2014 / Published: 26 August 2014
(This article belongs to the Section Organic Synthesis)
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Abstract

A rapid and efficient solvent-free one-pot synthesis of coumarin derivatives by Pechmann condensation reactions of phenols with ethyl acetoacetate using FeF3 as a catalyst under microwave irradiation is described. This one-pot synthesis on a solid inorganic support provides the products in good yields. The newly synthesized compounds were systematically characterized by IR, 1H-NMR, 13C-NMR, MS and elemental CHN analyses. The proposed solvent-free microwave irradiation method using the environmentally friendly catalyst FeF3 offers the unique advantages of high yields, shorter reaction times, easy and quick isolation of the products, excellent chemoselectivity, and a one-pot, green synthesis. The products were screened for antimicrobial activity, and the results showed that the compounds reacted against all the tested bacteria. View Full-Text
Keywords: coumarin; solvent-free; FeF3; one-pot; microwave irradiation; antimicrobial activities coumarin; solvent-free; FeF3; one-pot; microwave irradiation; antimicrobial activities
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Vahabi, V.; Hatamjafari, F. Microwave Assisted Convenient One-Pot Synthesis of Coumarin Derivatives via Pechmann Condensation Catalyzed by FeF3 under Solvent-Free Conditions and Antimicrobial Activities of the Products. Molecules 2014, 19, 13093-13103.

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