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Molecules 2014, 19(8), 12368-12420; doi:10.3390/molecules190812368

Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research

Bergische Universität Wuppertal, Fachgruppe C, Organic Chemistry, Gaußstraße 20, Wuppertal 42119, Germany
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Received: 11 July 2014 / Revised: 4 August 2014 / Accepted: 4 August 2014 / Published: 15 August 2014
(This article belongs to the Special Issue Peptide Chemistry)

Abstract

Faced with the need to find new drugs for all kinds of diseases, science sees that Nature offers numerous classes of compounds showing an impressively high biological potential. Among those are the cyclodepsipeptides, hybrid structures composed of amino and hydroxy acids. In the past decades numerous cyclodepsipeptides have been isolated and their potential as drugs has been studied extensively. For several cyclodepsipeptides total syntheses both in solution and on solid-phase have been established, allowing the production of combinatorial libraries. In addition, the biosynthesis of specific cyclodepsipeptides has been elucidated and used for the chemoenzymatic preparation of nonnatural analogues. This review summarizes the recent literature on cyclic tetra- to decadepsipeptides, composed exclusively of α-amino- and α-hydroxy acids. View Full-Text
Keywords: natural product; cyclodepsipeptide; solid-phase synthesis; biological activity; total synthesis natural product; cyclodepsipeptide; solid-phase synthesis; biological activity; total synthesis
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sivanathan, S.; Scherkenbeck, J. Cyclodepsipeptides: A Rich Source of Biologically Active Compounds for Drug Research. Molecules 2014, 19, 12368-12420.

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