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Molecules 2014, 19(7), 9628-9654; doi:10.3390/molecules19079628

Ruthenium Complexes as NO Donors for Vascular Relaxation Induction

Faculdade de Ciências Integradas do Pontal, Universidade Federal de Uberlândia, Ituiutaba 38304-402, MG, Brazil
Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, SP, Brazil
Author to whom correspondence should be addressed.
Received: 8 April 2014 / Revised: 9 June 2014 / Accepted: 26 June 2014 / Published: 7 July 2014
(This article belongs to the Special Issue Ruthenium Complex)
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Nitric oxide (NO) donors are substances that can release NO. Vascular relaxation induction is among the several functions of NO, and the administration of NO donors is a pharmacological alternative to treat hypertension. This review will focus on the physicochemical description of ruthenium-derived NO donor complexes that release NO via reduction and light stimulation. In particular, we will discuss the complexes synthesized by our research group over the last ten years, and we will focus on the vasodilation and arterial pressure control elicited by these complexes. Soluble guanylyl cyclase (sGC) and potassium channels are the main targets of the NO species released from the inorganic compounds. We will consider the importance of the chemical structure of the ruthenium complexes and their vascular effects. View Full-Text
Keywords: nitric oxide; ruthenium-derived complexes; vasodilation; blood pressure control; soluble guanylyl cyclase; potassium channels nitric oxide; ruthenium-derived complexes; vasodilation; blood pressure control; soluble guanylyl cyclase; potassium channels

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

de Lima, R.G.; Silva, B.R.; da Silva, R.S.; Bendhack, L.M. Ruthenium Complexes as NO Donors for Vascular Relaxation Induction. Molecules 2014, 19, 9628-9654.

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