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Molecules 2014, 19(7), 9240-9256; doi:10.3390/molecules19079240

The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation

1
Department of Therapeutic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 Ion Creanga Street, 400010 Cluj-Napoca, Romania
2
Department of Physiopathology, Faculty of Medicine, "Iuliu Haţieganu" University of Medicine and Pharmacy, 2-4 Victor Babes Street, 400010 Cluj-Napoca, Romania
3
Department of Pharmacognosy, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, 12 I. Creanga Street, 400010 Cluj-Napoca, Romania
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 12 May 2014 / Revised: 24 June 2014 / Accepted: 27 June 2014 / Published: 2 July 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Nineteen bisthiazoles were tested in order to assess their anti-inflammatory and antioxidant properties. First, we evaluated the in vitro direct antioxidant capacity of the bisthiazoles using the DPPH radical scavenging method. Then, the anti-inflammatory effect was tested in acute rat experimental inflammation by measuring the acute phase bone marrow response, the phagocytic capacity and the serum nitro-oxidative stress status. Although none of the substances showed significant direct antioxidant potential in the DPPH assay, most of them improved serum oxidative status, when administered to rats with inflammation. Four of the bisthiazoles proved to have good anti-inflammatory properties, similar or superior to that of equal doses meloxicam. View Full-Text
Keywords: anti-inflammatory; nitro-oxidative stress; iNOS; bisthiazoles; antioxidant anti-inflammatory; nitro-oxidative stress; iNOS; bisthiazoles; antioxidant
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MDPI and ACS Style

Araniciu, C.; Pârvu, A.E.; Palage, M.D.; Oniga, S.D.; Benedec, D.; Oniga, I.; Oniga, O. The Effect of Some 4,2 and 5,2 Bisthiazole Derivatives on Nitro-Oxidative Stress and Phagocytosis in Acute Experimental Inflammation. Molecules 2014, 19, 9240-9256.

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