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Molecules 2014, 19(7), 9257-9272; doi:10.3390/molecules19079257

Protective Effects of Baccharis dracunculifolia Leaves Extract against Carbon Tetrachloride- and Acetaminophen-Induced Hepatotoxicity in Experimental Animals

1
Identificação e Pesquisa em Princípios Ativos Naturais - NIPPAN, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n – Campus Universitário, Bairro São Pedro, CEP36036-900, Juiz de Fora, MG, Brazil
2
Laboratório de Bioatividade Celular e Molecular, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n – Campus Universitário, Bairro São Pedro, CEP36036-900, Juiz de Fora, MG, Brazil
3
Laboratório de Imunopatologia e Patologia Experimental, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n – Campus Universitário, Bairro São Pedro, CEP36036-900, Juiz de Fora, MG, Brazil
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Laboratório de Farmacologia de Produtos Naturais, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer, s/n – Campus Universitário, Bairro São Pedro, CEP36036-900, Juiz de Fora, MG, Brazil
*
Author to whom correspondence should be addressed.
Received: 14 May 2014 / Revised: 25 June 2014 / Accepted: 26 June 2014 / Published: 2 July 2014
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [576 KB, uploaded 2 July 2014]   |  

Abstract

In this work we investigated the in vivo protective effects of Baccharis dracunculifolia leaves extract (BdE) against carbon tetrachloride (CCl4)- and acetaminophen (APAP)-induced hepatotoxicity. Total phenolic content, total flavonoid content, antioxidant DPPH radical scavenging activity, and HPLC analysis were performed. Our results showed that pretreatment with BdE significantly reduced the damage caused by CCl4 and APAP on the serum markers of hepatic injury, AST, ALT, and ALP. Results were confirmed by histopathological analysis. Phytochemical analysis, performed by HPLC, showed that BdE was rich in p-coumaric acid derivatives, caffeoylquinic acids and flavonoids. BdE also showed DPPH antioxidant activity (EC50 of 15.75 ± 0.43 μg/mL), and high total phenolic (142.90 ± 0.77 mg GAE/g) and flavonoid (51.47 ± 0.60 mg RE/g) contents. This study indicated that B. dracunculifolia leaves extract has relevant in vivo hepatoprotective properties. View Full-Text
Keywords: Baccharis dracunculifolia; Brazilian green propolis; acetaminophen; carbon tetrachloride; hepatoprotective Baccharis dracunculifolia; Brazilian green propolis; acetaminophen; carbon tetrachloride; hepatoprotective
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MDPI and ACS Style

Rezende, T.P.; Corrêa, J.O.A.; Aarestrup, B.J.V.; Aarestrup, F.M.; de Sousa, O.V.; da Silva Filho, A.A. Protective Effects of Baccharis dracunculifolia Leaves Extract against Carbon Tetrachloride- and Acetaminophen-Induced Hepatotoxicity in Experimental Animals. Molecules 2014, 19, 9257-9272.

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