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Molecules 2014, 19(7), 8981-8994; doi:10.3390/molecules19078981

MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes

1
ENT, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania
2
Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest 30932, Romania
3
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania
4
AMG Transcend, Polizu Street no 1-7, Bucharest 011061, Romania
5
Departamento de Química Fisica, Universidade de Vigo, 36310 Vigo, Pontevedra, Spain
6
National Institute for Lasers, Plasma & Radiation Physics, Lasers Department, P.O. Box MG-36, Bucharest-Magurele, Bucharest 769231, Romania
7
Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" (ICBP), Bucharest 050568, Romania
8
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, AleeaPortocalelor no 1-3, Bucharest 060101, Romania
*
Author to whom correspondence should be addressed.
Received: 20 May 2014 / Revised: 14 June 2014 / Accepted: 23 June 2014 / Published: 27 June 2014
(This article belongs to the Special Issue Bio and Nanomaterials Based on Fe3O4)
View Full-Text   |   Download PDF [1996 KB, uploaded 27 June 2014]   |  

Abstract

Cinnamomum verum-functionalized Fe3O4 nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe3O4@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization. View Full-Text
Keywords: magnetite nanoparticles; drug delivery; MAPLE; laser processing; essential oils; natural products magnetite nanoparticles; drug delivery; MAPLE; laser processing; essential oils; natural products
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Anghel, A.G.; Grumezescu, A.M.; Chirea, M.; Grumezescu, V.; Socol, G.; Iordache, F.; Oprea, A.E.; Anghel, I.; Holban, A.M. MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes. Molecules 2014, 19, 8981-8994.

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