Molecules 2014, 19(7), 8981-8994; doi:10.3390/molecules19078981
Article

MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes

1,2email, 3,4email, 5,* email, 3,4,6email, 6email, 7email, 3email, 1,2email and 3,4,8email
Received: 20 May 2014; in revised form: 14 June 2014 / Accepted: 23 June 2014 / Published: 27 June 2014
(This article belongs to the Special Issue Bio and Nanomaterials Based on Fe3O4)
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Abstract: Cinnamomum verum-functionalized Fe3O4 nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe3O4@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization.
Keywords: magnetite nanoparticles; drug delivery; MAPLE; laser processing; essential oils; natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Anghel, A.G.; Grumezescu, A.M.; Chirea, M.; Grumezescu, V.; Socol, G.; Iordache, F.; Oprea, A.E.; Anghel, I.; Holban, A.M. MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes. Molecules 2014, 19, 8981-8994.

AMA Style

Anghel AG, Grumezescu AM, Chirea M, Grumezescu V, Socol G, Iordache F, Oprea AE, Anghel I, Holban AM. MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes. Molecules. 2014; 19(7):8981-8994.

Chicago/Turabian Style

Anghel, Alina G.; Grumezescu, Alexandru M.; Chirea, Mariana; Grumezescu, Valentina; Socol, Gabriel; Iordache, Florin; Oprea, Alexandra E.; Anghel, Ion; Holban, Alina M. 2014. "MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes." Molecules 19, no. 7: 8981-8994.


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