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Molecules 2014, 19(7), 8981-8994; doi:10.3390/molecules19078981
Article

MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes

1,2
, 3,4
, 5,* , 3,4,6
, 6
, 7
, 3
, 1,2
 and 3,4,8
1 ENT, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania 2 Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest 30932, Romania 3 Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania 4 AMG Transcend, Polizu Street no 1-7, Bucharest 011061, Romania 5 Departamento de Química Fisica, Universidade de Vigo, 36310 Vigo, Pontevedra, Spain 6 National Institute for Lasers, Plasma & Radiation Physics, Lasers Department, P.O. Box MG-36, Bucharest-Magurele, Bucharest 769231, Romania 7 Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" (ICBP), Bucharest 050568, Romania 8 Microbiology Immunology Department, Faculty of Biology, University of Bucharest, AleeaPortocalelor no 1-3, Bucharest 060101, Romania
* Author to whom correspondence should be addressed.
Received: 20 May 2014 / Revised: 14 June 2014 / Accepted: 23 June 2014 / Published: 27 June 2014
(This article belongs to the Special Issue Bio and Nanomaterials Based on Fe3O4)
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Abstract

Cinnamomum verum-functionalized Fe3O4 nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe3O4@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization.
Keywords: magnetite nanoparticles; drug delivery; MAPLE; laser processing; essential oils; natural products magnetite nanoparticles; drug delivery; MAPLE; laser processing; essential oils; natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Anghel, A.G.; Grumezescu, A.M.; Chirea, M.; Grumezescu, V.; Socol, G.; Iordache, F.; Oprea, A.E.; Anghel, I.; Holban, A.M. MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes. Molecules 2014, 19, 8981-8994.

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