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Molecules 2014, 19(7), 8981-8994; doi:10.3390/molecules19078981
Article

MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes

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1 ENT, "Carol Davila" University of Medicine and Pharmacy, Traian Vuia no.6, Bucharest 020956, Romania 2 Doctor Anghel Medical Center, Theodor Sperantia Street, Bucharest 30932, Romania 3 Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street no 1-7, Bucharest 011061, Romania 4 AMG Transcend, Polizu Street no 1-7, Bucharest 011061, Romania 5 Departamento de Química Fisica, Universidade de Vigo, 36310 Vigo, Pontevedra, Spain 6 National Institute for Lasers, Plasma & Radiation Physics, Lasers Department, P.O. Box MG-36, Bucharest-Magurele, Bucharest 769231, Romania 7 Flow Cytometry and Cell Therapy Laboratory, Institute of Cellular Biology and Pathology "Nicolae Simionescu" (ICBP), Bucharest 050568, Romania 8 Microbiology Immunology Department, Faculty of Biology, University of Bucharest, AleeaPortocalelor no 1-3, Bucharest 060101, Romania
* Author to whom correspondence should be addressed.
Received: 20 May 2014 / Revised: 14 June 2014 / Accepted: 23 June 2014 / Published: 27 June 2014
(This article belongs to the Special Issue Bio and Nanomaterials Based on Fe3O4)
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Abstract

Cinnamomum verum-functionalized Fe3O4 nanoparticles of 9.4 nm in size were laser transferred by matrix assisted pulsed laser evaporation (MAPLE) technique onto gastrostomy tubes (G-tubes) for antibacterial activity evaluation toward Gram positive and Gram negative microbial colonization. X-ray diffraction analysis of the nanoparticle powder showed a polycrystalline magnetite structure, whereas infrared mapping confirmed the integrity of C. verum (CV) functional groups after the laser transfer. The specific topography of the deposited films involved a uniform thin coating together with several aggregates of bio-functionalized magnetite particles covering the G-tubes. Cytotoxicity assays showed an increase of the G-tube surface biocompatibility after Fe3O4@CV treatment, allowing a normal development of endothelial cells up to five days of incubation. Microbiological assays on nanoparticle-modified G-tube surfaces have proved an improvement of anti-adherent properties, significantly reducing both Gram negative and Gram positive bacteria colonization.
Keywords: magnetite nanoparticles; drug delivery; MAPLE; laser processing; essential oils; natural products magnetite nanoparticles; drug delivery; MAPLE; laser processing; essential oils; natural products
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Anghel, A.G.; Grumezescu, A.M.; Chirea, M.; Grumezescu, V.; Socol, G.; Iordache, F.; Oprea, A.E.; Anghel, I.; Holban, A.M. MAPLE Fabricated Fe3O4@Cinnamomum verum Antimicrobial Surfaces for Improved Gastrostomy Tubes. Molecules 2014, 19, 8981-8994.

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