Next Article in Journal
Selective Substitution of 31/42–OH in Rapamycin Guided by an in Situ IR Technique
Next Article in Special Issue
Polyphenol-Rich Strawberry Extract Protects Human Dermal Fibroblasts against Hydrogen Peroxide Oxidative Damage and Improves Mitochondrial Functionality
Previous Article in Journal
Methods of Increasing the Performance of Radionuclide Generators Used in Nuclear Medicine: Daughter Nuclide Build-Up Optimisation, Elution-Purification-Concentration Integration, and Effective Control of Radionuclidic Purity
Previous Article in Special Issue
Role of Oligomeric Proanthocyanidins Derived from an Extract of Persimmon Fruits in the Oxidative Stress-Related Aging Process
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(6), 7757-7769; doi:10.3390/molecules19067757

Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress

1
School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China
2
Research & Development Centre, Infinitus (China) Company Ltd, Guangzhou 510665, China
3
Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 May 2014 / Revised: 30 May 2014 / Accepted: 5 June 2014 / Published: 10 June 2014
(This article belongs to the Special Issue Natural Antioxidants and Ageing)
View Full-Text   |   Download PDF [469 KB, uploaded 18 June 2014]   |  

Abstract

Polyglutamine (polyQ) aggregation plays a pivotal role in the pathological process of Huntington’s disease and other polyQ disorders. Therefore, strategies aiming at restoring dysfunction and reducing stresses mediated by polyQ toxicity are of therapeutic interest for proteotoxicity diseases. Salidroside, a glycoside from Rhodiola rosea, has been shown to have a variety of bioactivities, including antioxidant activity. Using transgenic Caenorhabditis elegans models, we show here that salidroside is able to reduce neuronal death and behavioral dysfunction mediated by polyQ expressed in ASH neurons, but the neuroprotective effect is not associated with prevention of polyQ aggregation per se. Further experiments reveal that the neuroprotective effect of salidroside in C. elegans models involves its antioxidant capabilities, including decrease of ROS levels and paraquat-induced mortality, increase of antioxidant enzyme activities and reduction of lipid peroxidation. These results demonstrate that salidroside exerts its neuroprotective function against polyQ toxicity via oxidative stress pathways. View Full-Text
Keywords: salidroside; polyglutamine; neurotoxicity; oxidative stress; C. elegans; chemoavoidance salidroside; polyglutamine; neurotoxicity; oxidative stress; C. elegans; chemoavoidance
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xiao, L.; Li, H.; Zhang, J.; Yang, F.; Huang, A.; Deng, J.; Liang, M.; Ma, F.; Hu, M.; Huang, Z. Salidroside Protects Caenorhabditis elegans Neurons from Polyglutamine-Mediated Toxicity by Reducing Oxidative Stress. Molecules 2014, 19, 7757-7769.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top