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Molecules 2014, 19(6), 7169-7188; doi:10.3390/molecules19067169
Review

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

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1 MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China 2 Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China
* Authors to whom correspondence should be addressed.
Received: 6 May 2014 / Revised: 23 May 2014 / Accepted: 27 May 2014 / Published: 30 May 2014
(This article belongs to the Section Natural Products)
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Abstract

Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.
Keywords: bis-naphtho-γ-pyrones; chaetochromin; asperpyrone; nigerone; fungi; biological activities bis-naphtho-γ-pyrones; chaetochromin; asperpyrone; nigerone; fungi; biological activities
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Lu, S.; Tian, J.; Sun, W.; Meng, J.; Wang, X.; Fu, X.; Wang, A.; Lai, D.; Liu, Y.; Zhou, L. Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities. Molecules 2014, 19, 7169-7188.

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