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Molecules 2014, 19(6), 7169-7188; doi:10.3390/molecules19067169

Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities

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1 MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China 2 Institute of Agro-products Processing Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China
* Authors to whom correspondence should be addressed.
Received: 6 May 2014 / Revised: 23 May 2014 / Accepted: 27 May 2014 / Published: 30 May 2014
(This article belongs to the Section Metabolites)
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Bis-naphtho-γ-pyrones are an important group of aromatic polyketides derived from fungi. They have a variety of biological activities including cytotoxic, antitumor, antimicrobial, tyrosine kinase and HIV-1 integrase inhibition properties, demonstrating their potential applications in medicine and agriculture. At least 59 bis-naphtho-γ-pyrones from fungi have been reported in the past few decades. This mini-review aims to briefly summarize their occurrence, biosynthesis, and structure, as well as their biological activities. Some considerations regarding to synthesis, production, and medicinal and agricultural applications of bis-naphtho-γ-pyrones are also discussed.
Keywords: bis-naphtho-γ-pyrones; chaetochromin; asperpyrone; nigerone; fungi; biological activities bis-naphtho-γ-pyrones; chaetochromin; asperpyrone; nigerone; fungi; biological activities
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Lu, S.; Tian, J.; Sun, W.; Meng, J.; Wang, X.; Fu, X.; Wang, A.; Lai, D.; Liu, Y.; Zhou, L. Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities. Molecules 2014, 19, 7169-7188.

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