Molecules 2014, 19(5), 6393-6406; doi:10.3390/molecules19056393
The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment
1
Department of Medical Oncology, Università Politecnica delle Marche, A.O.U. "Ospedali Riuniti" Via Conca 71, 60126 Ancona, Italy
2
Istituto Oncologico "Giovanni Paolo II", I.R.C.S.S. Ospedale Oncologico di Bari, Viale Orazio Flacco 65, 70124 Bari, Italy
*
Author to whom correspondence should be addressed.
Received: 27 February 2014 / Revised: 2 May 2014 / Accepted: 15 May 2014 / Published: 19 May 2014
(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)
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Abstract
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation. Recent evidences have shown that they are involved in many biological processes, from development and cell-cycle regulation to apoptosis. miRNAs can behave as tumor suppressor or promoter of oncogenesis depending on the cellular function of their targets. Moreover, they are frequently dysregulated in HCC. In this review we summarize the latest findings of miRNAs regulation in HCC and their role as potentially diagnostic and prognostic biomarkers for HCC. We highlight development of miRNAs as potential therapeutic targets for HCC.Keywords:
HCC; hepatocellular carcinoma; miRNAs
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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MDPI and ACS Style
D'Anzeo, M.; Faloppi, L.; Scartozzi, M.; Giampieri, R.; Bianconi, M.; Del Prete, M.; Silvestris, N.; Cascinu, S. The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment. Molecules 2014, 19, 6393-6406.
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