The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment

doi:10.3390/molecules19056393

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Molecules 2014, 19(5), 6393-6406; doi:10.3390/molecules19056393

Review

The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment

Marco D'Anzeo¹

, Luca Faloppi¹

, Mario Scartozzi^1,* , Riccardo Giampieri¹

, Maristella Bianconi¹

, Michela Del Prete¹

, Nicola Silvestris²

and Stefano Cascinu¹

+ Authors' affiliations

Received: 27 February 2014 / Revised: 2 May 2014 / Accepted: 15 May 2014 / Published: 19 May 2014

(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)

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Abstract: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third leading cause of cancer deaths. microRNAs (miRNAs) are evolutionary conserved small non-coding RNA that negatively regulate gene expression and protein translation. Recent evidences have shown that they are involved in many biological processes, from development and cell-cycle regulation to apoptosis. miRNAs can behave as tumor suppressor or promoter of oncogenesis depending on the cellular function of their targets. Moreover, they are frequently dysregulated in HCC. In this review we summarize the latest findings of miRNAs regulation in HCC and their role as potentially diagnostic and prognostic biomarkers for HCC. We highlight development of miRNAs as potential therapeutic targets for HCC.

Keywords: HCC; hepatocellular carcinoma; miRNAs

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

D'Anzeo, M.; Faloppi, L.; Scartozzi, M.; Giampieri, R.; Bianconi, M.; Del Prete, M.; Silvestris, N.; Cascinu, S. The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment. Molecules 2014, 19, 6393-6406.

AMA Style

D'Anzeo M, Faloppi L, Scartozzi M, Giampieri R, Bianconi M, Del Prete M, Silvestris N, Cascinu S. The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment. Molecules. 2014; 19(5):6393-6406.

Chicago/Turabian Style

D'Anzeo, Marco; Faloppi, Luca; Scartozzi, Mario; Giampieri, Riccardo; Bianconi, Maristella; Del Prete, Michela; Silvestris, Nicola; Cascinu, Stefano. 2014. "The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment." Molecules 19, no. 5: 6393-6406.

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