Next Article in Journal
2,5-PRODAN Derivatives as Highly Sensitive Sensors of Low Solvent Acidity
Previous Article in Journal
The role of Micro-RNAs in Hepatocellular Carcinoma: From Molecular Biology to Treatment
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(5), 6407-6414; doi:10.3390/molecules19056407

CopA3 Peptide Prevents Ultraviolet-Induced Inhibition of Type-I Procollagen and Induction of Matrix Metalloproteinase-1 in Human Skin Fibroblasts

1
Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan 712-260, Korea
2
Advanced Medical Fusion Textile Center, Gyeongbuk Technopark Foundation, Gyeongsan 712-210, Korea
3
Department of Cosmeceutical Science, Daegu Haany University, Gyeongsan 712-715, Korea
4
Radiation Division for Biotechnology, Advanced Radiation Technology Institute, Jeongeup Campus of Atomic Energy Research Institute (KAERI), Jeonbuk 580-185, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 9 April 2014 / Revised: 10 May 2014 / Accepted: 12 May 2014 / Published: 20 May 2014
View Full-Text   |   Download PDF [300 KB, uploaded 18 June 2014]   |  

Abstract

Ultraviolet (UV) exposure is well-known to induce premature aging, which is mediated by matrix metalloproteinase-1 (MMP-1) activity. A 9-mer peptide, CopA3 (CopA3) was synthesized from a natural peptide, coprisin, which is isolated from the dung beetle Copris tripartitus. As part of our continuing search for novel bioactive natural products, CopA3 was investigated for its in vitro anti-skin photoaging activity. UV-induced inhibition of type-I procollagen and induction of MMP-1 were partially prevented in human skin fibroblasts by CopA3 peptide in a dose-dependent manner. At a concentration of 25 μM, CopA3 nearly completely inhibited MMP-1 expression. These results suggest that CopA3, an insect peptide, is a potential candidate for the prevention and treatment of skin aging.
Keywords: Copris tripartitus; CopA3; ultraviolet; matrix metalloproteinase-1; CCD-986sk cells Copris tripartitus; CopA3; ultraviolet; matrix metalloproteinase-1; CCD-986sk cells
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, D.-H.; Kim, H.-H.; Kim, H.-J.; Jung, H.-G.; Yu, J.-M.; Lee, E.-S.; Cho, Y.-H.; Kim, D.-I.; An, B.-J. CopA3 Peptide Prevents Ultraviolet-Induced Inhibition of Type-I Procollagen and Induction of Matrix Metalloproteinase-1 in Human Skin Fibroblasts. Molecules 2014, 19, 6407-6414.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top