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Molecules 2014, 19(5), 6407-6414; doi:10.3390/molecules19056407
Article

CopA3 Peptide Prevents Ultraviolet-Induced Inhibition of Type-I Procollagen and Induction of Matrix Metalloproteinase-1 in Human Skin Fibroblasts

1,†, 2,†, 3, 4, 3, 3, 3, 3 and 3,*
1 Korea Promotion Institute for Traditional Medicine Industry, Gyeongsan 712-260, Korea 2 Advanced Medical Fusion Textile Center, Gyeongbuk Technopark Foundation, Gyeongsan 712-210, Korea 3 Department of Cosmeceutical Science, Daegu Haany University, Gyeongsan 712-715, Korea 4 Radiation Division for Biotechnology, Advanced Radiation Technology Institute, Jeongeup Campus of Atomic Energy Research Institute (KAERI), Jeonbuk 580-185, Korea These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 9 April 2014 / Revised: 10 May 2014 / Accepted: 12 May 2014 / Published: 20 May 2014
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Abstract

Ultraviolet (UV) exposure is well-known to induce premature aging, which is mediated by matrix metalloproteinase-1 (MMP-1) activity. A 9-mer peptide, CopA3 (CopA3) was synthesized from a natural peptide, coprisin, which is isolated from the dung beetle Copris tripartitus. As part of our continuing search for novel bioactive natural products, CopA3 was investigated for its in vitro anti-skin photoaging activity. UV-induced inhibition of type-I procollagen and induction of MMP-1 were partially prevented in human skin fibroblasts by CopA3 peptide in a dose-dependent manner. At a concentration of 25 μM, CopA3 nearly completely inhibited MMP-1 expression. These results suggest that CopA3, an insect peptide, is a potential candidate for the prevention and treatment of skin aging.
Keywords: Copris tripartitus; CopA3; ultraviolet; matrix metalloproteinase-1; CCD-986sk cells Copris tripartitus; CopA3; ultraviolet; matrix metalloproteinase-1; CCD-986sk cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, D.-H.; Kim, H.-H.; Kim, H.-J.; Jung, H.-G.; Yu, J.-M.; Lee, E.-S.; Cho, Y.-H.; Kim, D.-I.; An, B.-J. CopA3 Peptide Prevents Ultraviolet-Induced Inhibition of Type-I Procollagen and Induction of Matrix Metalloproteinase-1 in Human Skin Fibroblasts. Molecules 2014, 19, 6407-6414.

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