Next Article in Journal
Chemical Profile Analysis and Comparison of Two Versions of the Classic TCM Formula Danggui Buxue Tang by HPLC-DAD-ESI-IT-TOF-MSn
Previous Article in Journal
Effects of Piperine on the Intestinal Permeability and Pharmacokinetics of Linarin in Rats
Molecules 2014, 19(5), 5634-5649; doi:10.3390/molecules19055634
Article

β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats

, , ,  and *
Received: 8 March 2014; in revised form: 8 April 2014 / Accepted: 17 April 2014 / Published: 30 April 2014
(This article belongs to the Section Metabolites)
View Full-Text   |   Download PDF [725 KB, uploaded 18 June 2014]   |   Browse Figures
Abstract: In this study, we investigated the influence of β-asarone, the major ingredient of Acorus tatarinowii Schott, on depressive-like behavior induced by the chronic unpredictable mild stresses (CUMS) paradigm and to clarify the underlying mechanisms. The results show that β-asarone treatment partially reversed the CUMS-induced depression-like behaviors in both the forced swim and sucrose preference tests. The behavioral effects were associated with increased hippocampal neurogenesis indicated by bromodeoxyuridine (BrdU) immunoreactivity. β-Asarone treatment significantly increased the expression of brain-derived neurotrophic factor (BDNF) at levels of transcription and translation. Moreover, CUMS caused significant reduction in ERK1/2 and CREB phosphorylation, both of which were partially attenuated by β-asarone administration. It is important to note that β-asarone treatment had no effect on total levels or phosphorylation state of any of the proteins examined in ERK1/2-CREB pathway in no stress rats, suggesting that β-asarone acts in a stress-dependent manner to block ERK1/2-CREB signaling. We did not observe a complete reversal of depression-like behaviors to control levels by β-asarone. To our knowledge, the present study is the first to demonstrate that adult neurogenesis is involved in the antidepressant-like behavioral effects of β-asarone, suggesting that β-asarone is a promising candidate for the treatment of depression.
Keywords: depression; β-asarone; brain-derived neurotrophic factor; neurogenesis depression; β-asarone; brain-derived neurotrophic factor; neurogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Dong, H.; Gao, Z.; Rong, H.; Jin, M.; Zhang, X. β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats. Molecules 2014, 19, 5634-5649.

AMA Style

Dong H, Gao Z, Rong H, Jin M, Zhang X. β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats. Molecules. 2014; 19(5):5634-5649.

Chicago/Turabian Style

Dong, Haiying; Gao, Zhiying; Rong, Hua; Jin, Ming; Zhang, Xiaojie. 2014. "β-Asarone Reverses Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior and Promotes Hippocampal Neurogenesis in Rats." Molecules 19, no. 5: 5634-5649.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert