Next Article in Journal
Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae)
Previous Article in Journal
Two Ellagic Acids Isolated from Roots of Sanguisorba officinalis L. Promote Hematopoietic Progenitor Cell Proliferation and Megakaryocyte Differentiation
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(5), 5459-5469; doi:10.3390/molecules19055459

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

1
Photochemistry Department, National Research Center, Dokki, Cairo 1258943, Egypt
2
Chemistry Department, Faculty of Science and Human Studies, Shaqra University, Huraiymla 11961, Kingdom of Saudi Arabia
3
Chemistry Department, Faculty of Science, Hail University, Hail 81411, Kingdom of Saudi Arabia
4
Chemistry Department, Faculty of Education, Shaqra University, Afif 11921, Kingdom of Saudi Arabia
5
Food Science and Nutrition Department, College of Food Science and Agriculture, King Saud University, Riyadh 11564, Kingdom of Saudi Arabia
*
Author to whom correspondence should be addressed.
Received: 30 March 2014 / Revised: 16 April 2014 / Accepted: 17 April 2014 / Published: 25 April 2014
(This article belongs to the Section Organic Synthesis)
View Full-Text   |   Download PDF [239 KB, uploaded 18 June 2014]   |  

Abstract

4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions were reported. Moreover, the syntheses of 2-substituted-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 10 and 11 was described. View Full-Text
Keywords: pyrazoles; pyrazolopyrimidines; pyrazolotriazolopyrimidines; isomerization pyrazoles; pyrazolopyrimidines; pyrazolotriazolopyrimidines; isomerization
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rashad, A.E.; Shamroukh, A.H.; Abdel-Megeid, R.E.; Ali, H.S. Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives. Molecules 2014, 19, 5459-5469.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top