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Molecules 2014, 19(5), 5459-5469; doi:10.3390/molecules19055459

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

1,2,* , 1,3
1 Photochemistry Department, National Research Center, Dokki, Cairo 1258943, Egypt 2 Chemistry Department, Faculty of Science and Human Studies, Shaqra University, Huraiymla 11961, Kingdom of Saudi Arabia 3 Chemistry Department, Faculty of Science, Hail University, Hail 81411, Kingdom of Saudi Arabia 4 Chemistry Department, Faculty of Education, Shaqra University, Afif 11921, Kingdom of Saudi Arabia 5 Food Science and Nutrition Department, College of Food Science and Agriculture, King Saud University, Riyadh 11564, Kingdom of Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 30 March 2014 / Revised: 16 April 2014 / Accepted: 17 April 2014 / Published: 25 April 2014
(This article belongs to the Section Organic Synthesis)
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4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions were reported. Moreover, the syntheses of 2-substituted-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 10 and 11 was described.
Keywords: pyrazoles; pyrazolopyrimidines; pyrazolotriazolopyrimidines; isomerization pyrazoles; pyrazolopyrimidines; pyrazolotriazolopyrimidines; isomerization
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Rashad, A.E.; Shamroukh, A.H.; Abdel-Megeid, R.E.; Ali, H.S. Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives. Molecules 2014, 19, 5459-5469.

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