Molecules 2014, 19(5), 5459-5469; doi:10.3390/molecules19055459
Article

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives

1,2,* , 1,3
, 1,4
 and 5
Received: 30 March 2014; in revised form: 16 April 2014 / Accepted: 17 April 2014 / Published: 25 April 2014
(This article belongs to the Section Organic Synthesis)
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Abstract: 4-Imino-1-p-tolyl-1,4-dihydropyrazolo[3,4-d]pyrimidin-5-ylamine (2) and (1-p-tolyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-hydrazine (3) were prepared starting from ethyl 4-cyano-1-p-tolyl-1H-pyrazol-5-ylimidoformate (1). The structure of compound 3 was confirmed through preparation of the pyrazole derivatives 4 and 5. Also, the synthesis and structural characterization of pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives 7 and 9 and their isomerization to pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 6 and 8, respectively, under different suitable reaction conditions were reported. Moreover, the syntheses of 2-substituted-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives 10 and 11 was described.
Keywords: pyrazoles; pyrazolopyrimidines; pyrazolotriazolopyrimidines; isomerization
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MDPI and ACS Style

Rashad, A.E.; Shamroukh, A.H.; Abdel-Megeid, R.E.; Ali, H.S. Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives. Molecules 2014, 19, 5459-5469.

AMA Style

Rashad AE, Shamroukh AH, Abdel-Megeid RE, Ali HS. Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives. Molecules. 2014; 19(5):5459-5469.

Chicago/Turabian Style

Rashad, Aymn E.; Shamroukh, Ahmed H.; Abdel-Megeid, Randa E.; Ali, Hatem S. 2014. "Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives." Molecules 19, no. 5: 5459-5469.


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