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Molecules 2014, 19(4), 5379-5401; doi:10.3390/molecules19045379
Review

Role of MicroRNA in Response to Ionizing Radiations: Evidences and Potential Impact on Clinical Practice for Radiotherapy

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Received: 10 February 2014; in revised form: 17 April 2014 / Accepted: 23 April 2014 / Published: 24 April 2014
(This article belongs to the Special Issue miRNAs as Probes to Monitor Cancer and Neurodegenerative Disorders)
View Full-Text   |   Download PDF [293 KB, uploaded 18 June 2014]
Abstract: MicroRNAs (miRNA) are small, non-coding, RNAs with gene expression regulator roles. As an important class of regulators of many cellular pathways, miRNAs are involved in many signaling pathways and DNA damage repair processes, affecting cellular radiosensitivity. Their role has led to interest in oncological implications to improve treatment results. MiRNAs represent a great opportunity to enhance the efficacy of radiotherapy treatments—they can be used to profile the radioresistance of tumors before radiotherapy, monitor their response throughout the treatment, thus helping to select intensification strategies, and also to define the final response to therapy along with risks of recurrence or metastatization. Even though many interesting studies support such potential, nowadays most studies on patient data are limited to experiments profiling tumor aggressiveness and response to radiotherapy. Moreover many studies report different although not conflicting results on the miRNAs evaluated for each tumor type. Without doubt, the clinical potential of such molecules for radiotherapy is striking and of high interest.
Keywords: miRNA; miRNAs; microRNA; radiation; radiotherapy; resistance; review; tumor; DNA damage repair; radiosensibilization miRNA; miRNAs; microRNA; radiation; radiotherapy; resistance; review; tumor; DNA damage repair; radiosensibilization
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Cellini, F.; Morganti, A.G.; Genovesi, D.; Silvestris, N.; Valentini, V. Role of MicroRNA in Response to Ionizing Radiations: Evidences and Potential Impact on Clinical Practice for Radiotherapy. Molecules 2014, 19, 5379-5401.

AMA Style

Cellini F, Morganti AG, Genovesi D, Silvestris N, Valentini V. Role of MicroRNA in Response to Ionizing Radiations: Evidences and Potential Impact on Clinical Practice for Radiotherapy. Molecules. 2014; 19(4):5379-5401.

Chicago/Turabian Style

Cellini, Francesco; Morganti, Alessio G.; Genovesi, Domenico; Silvestris, Nicola; Valentini, Vincenzo. 2014. "Role of MicroRNA in Response to Ionizing Radiations: Evidences and Potential Impact on Clinical Practice for Radiotherapy." Molecules 19, no. 4: 5379-5401.



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