Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds
Abstract
:1. Introduction
2. Results
Modification | Glyoxal | Methylglyoxal |
---|---|---|
AGE formation | 10.4 | 22.7 |
Dityrosine formation | 48.9 | 121.3 |
N-Formylkynurenine formation | 11.3 | 27.1 |
Kynurenine formation | 12.5 | 19.0 |
Compound | AGE | Dityrosine | N′-formylkynurenine | Kynurenine |
---|---|---|---|---|
2,2,6,6-Tetramethyl-4-[(nonanoylamino)piperidin-1-yl]oxyl | 97.8 ± 4.78 | 96.25 ± 4.4 | 97.55 ± 4.41 | 326.09 ± 11.77 * |
3-Bromopyruvate | 216.01 ± 7.89 * | 208.88 ± 6.92 * | 221.49 ± 7.92 * | 120.5 ± 8.34 * |
4-Hydroxy-TEMPO | 80.54 ± 5.79 * | 75.62 ± 4.61 * | 78.33 ± 5.27 * | 162.6 ± 6.02 * |
Ascorbic acid | 104.4 ± 2.09 * | 111.97 ± 2.85 * | 109.21 ± 2.49 * | 182.54 ± 5.77 * |
Bisphenol A | 155.2 ± 5.22 * | 155.17 ± 3.91 * | 154.4 ± 3.68 * | 92.07 ± 4.51 * |
Captopril | 88.84 ± 3.17 * | 93.46 ± 3.4 * | 93.56 ± 4.41 * | 13.78 ± 0.45 * |
1-Cyano-4-hydroxycinnamic acid | 3.5 ± 0.213 * | 3.94 ± 0.09 * | 3.69 ± 0.16 * | 81.72 ± 5.24 * |
Cysteamine | 65.19 ± 2.69 * | 63.73 ± 2.84 * | 64.36 ± 2.97 * | 30.95 ± 0.47 * |
Ellagic acid | 47.02± 0.51 * | 35.49 ± 0.22 * | 45.6 ± 0.33 * | 48.1 ± 1.32 * |
Genistein | 27.17 ± 0.31 * | 25.98 ± 0.34 * | 27.92 ± 0.52 * | 85.90 ± 3.79 * |
4-Hydroxycinnamic acid | 91.78 ± 3.39 * | 92.35 ± 2.54 * | 89.67± 3.67 * | 89.4 ± 3.35 * |
Lipoic acid | 79.19 ± 2.42 * | 80.86 ± 2.33 * | 81.69 ± 2.79 * | 123.25 ± 4.41 * |
Metformin | 178.72 ± 5.34 * | 100.93 ± 2.6 | 163.44 ± 4.47 * | 146.51 ± 3.50 * |
Na-pyruvate | 100.52 ± 1.9 | 95.09 ± 1.75 * | 101.61 ± 2.22 | 63.33 ± 1.84 |
Naringin | 19.84 ± 0.68 | 16.87 ± 0.26 | 18.79 ± 0.49 | 69.32 ± 2.24 * |
para-Aminobenzoic acid | 46.25 ± 1.28 * | 46.43 ± 1.35 * | 46.59 ± 1.21 * | 111.84 ± 6.47 * |
Quinic acid | 57.29 ± 3.45 * | 57.27 ± 3.42 * | 61.35 ± 3.96 * | 128.99 ± 5.57 * |
TEMPO | 78.11 ± 3.45 * | 75.09 ± 3.22 * | 80.35 ± 3.48 * | 106.35 ± 4.13 * |
Tiron | 68.16 ± 4.16 * | 75.4 ± 4.15 * | 70.53 ± 4.54 * | 326.09 ± 11.77 * |
Compound | AGE | Dityrosine | N′-formylkynurenine | Kynurenine |
---|---|---|---|---|
2,2,6,6-Tetramethyl-4-[(nonanoylamino)piperidin-1-yl]oxyl | 80.94 ± 10.25 * | 82.6 ± 7.46 * | 82.03 ± 8.21 * | 74.68 ± 18.28 |
3-Bromopyruvate | 228.89 ± 11.14 * | 201.68 ± 8.82 * | 225.71 ± 9.33 * | 544.55 ± 28.26 * |
4-Hydroxy-TEMPO | 106.79 ± 11.96 | 104.33 ± 10.21 | 109.75 ± 11.15 | 116.48 ± 19.23 |
Ascorbic acid | 217.49 ± 3.3 * | 226.31 ± 3.09 * | 214.49 ± 2.97 * | 1233.03 ± 5.13 * |
Bisphenol A | 211.51 ± 4.41 * | 173.97 ± 5.28 * | 201.74 ± 3.91 * | 645.93 ± 17.76 * |
Captopril | 118.21 ± 5.33 * | 114.82 ± 5.69 * | 120.55 ± 5.96 * | 160.94 ± 11.56 * |
1-Cyano-4-hydroxycinnamic acid | 2.48 ± 0.45 * | 3.60 ± 0.36 * | 3.00 ± 0.45 * | 0.78 ± 1.27 * |
Cysteamine | 97.86 ± 14.26 | 90.96 ± 9.168 | 96.79 ± 10.56 | 221.00 ± 23.69 * |
Ellagic acid | 50.67 ± 0.53 * | 31.76 ± 0.17 * | 46.59 ± 0.45 * | 137.45 ± 2.28 * |
Genistein | 48.07 ± 1.11 * | 42.62 ± 1.01 * | 48.5± 0.99 * | 121.83 ± 7.36 * |
4-Hydroxycinnamic acid | 85.28 ± 6.09 * | 89.68 ± 8.33 * | 90.86 ± 11.44 | 117.76 ± 46.25 |
Lipoic acid | 98.7 ± 4.86 | 97.7 ± 4.13 | 105.12 ± 4.19 * | 122.04 ± 8.49 * |
Metformin | 112.98 ± 7.01 * | 118.51 ± 5.75 * | 118.95 ± 6.17 * | 140.2 ± 11.96 * |
Na-pyruvate | 146.55 ± 6.16 * | 138.77 ± 11.67 * | 143.83 ± 11.52 * | 221.12 ± 22.40 * |
Naringin | 37.86 ± 0.59 * | 28.18 ± 0.57 * | 35.88 ± 0.22 * | 206.21± 2.45 * |
para-Aminobenzoic acid | 94.7 ± 4.86 | 96.59 ± 4.42 | 99.59 ± 4.22 | 129.67± 8.2 * |
Quinic acid | 147.82 ± 10.8 * | 145.38 ± 8.21 * | 149.06 ± 8.75 * | 213.44 ± 14.32 * |
TEMPO | 101.77 ± 6.94 | 98.71 ± 6.32 | 113.51± 10.75 * | 133.52 ± 17.71 * |
Tiron | 95.96 ± 5.37 | 113.84 ± 9.77 * | 106.34 ± 10.88 | 170.80 ± 9.68 * |
3. Discussion
4. Experimental
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of interest
References
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Sadowska-Bartosz, I.; Galiniak, S.; Bartosz, G. Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds. Molecules 2014, 19, 4880-4896. https://doi.org/10.3390/molecules19044880
Sadowska-Bartosz I, Galiniak S, Bartosz G. Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds. Molecules. 2014; 19(4):4880-4896. https://doi.org/10.3390/molecules19044880
Chicago/Turabian StyleSadowska-Bartosz, Izabela, Sabina Galiniak, and Grzegorz Bartosz. 2014. "Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds" Molecules 19, no. 4: 4880-4896. https://doi.org/10.3390/molecules19044880