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Molecules 2014, 19(4), 4897-4906; doi:10.3390/molecules19044897

Three New Ring-A Modified Ursane Triterpenes from Davidia involucrata

2,4,*  and 3
Received: 26 March 2014 / Revised: 10 April 2014 / Accepted: 11 April 2014 / Published: 17 April 2014
(This article belongs to the Section Metabolites)
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Three new ursane triterpenes, 3α,19α-dihydroxy-2-nor-urs-12-en-23,28-dioic acid-23-methyl ester (1), 19α,23-dihydroxy-3-oxo-2-nor-urs-12-en-28-oic acid (2), and 2,3-seco-3-methoxy-3,19α,23-trihydroxy-urs-12-en-2-al-28-oic acid (3), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with six known compounds. Their structures were elucidated by means of various spectroscopic analyses. The isolated triterpenes provide important evolutionary and chemotaxonomic knowledge about the monotypic genus Davidia. Five of the identified compounds showed moderate cytotoxicities against the cell proliferation of SGC-7901, MCF-7, and BEL-7404 with IC50 range from 7.26 to 47.41 μM.
Keywords: Davidia involucrata; Nyssaceae; triterpenoids; cytotoxicity Davidia involucrata; Nyssaceae; triterpenoids; cytotoxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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Tan, Q.-W.; Ouyang, M.-A.; Gao, B. Three New Ring-A Modified Ursane Triterpenes from Davidia involucrata. Molecules 2014, 19, 4897-4906.

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