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Molecules 2014, 19(4), 4897-4906; doi:10.3390/molecules19044897

Three New Ring-A Modified Ursane Triterpenes from Davidia involucrata

1
Key Laboratory of Bio-pesticide and Chemistry-Biology, Ministry of Education, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
2
Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
3
Fujian International Travel Health Care Center, Fuzhou 350001, Fujian, China
4
Key Laboratory of Integrated Pest Management for Fujian-Taiwan Crops, Ministry of Agriculture, Fujian Agriculture and Forestry University, Fuzhou 350002, Fujian, China
*
Author to whom correspondence should be addressed.
Received: 26 March 2014 / Revised: 10 April 2014 / Accepted: 11 April 2014 / Published: 17 April 2014
(This article belongs to the Section Natural Products)
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Abstract

Three new ursane triterpenes, 3α,19α-dihydroxy-2-nor-urs-12-en-23,28-dioic acid-23-methyl ester (1), 19α,23-dihydroxy-3-oxo-2-nor-urs-12-en-28-oic acid (2), and 2,3-seco-3-methoxy-3,19α,23-trihydroxy-urs-12-en-2-al-28-oic acid (3), were isolated from the MeOH extract of the branch barks of Davidia involucrata, together with six known compounds. Their structures were elucidated by means of various spectroscopic analyses. The isolated triterpenes provide important evolutionary and chemotaxonomic knowledge about the monotypic genus Davidia. Five of the identified compounds showed moderate cytotoxicities against the cell proliferation of SGC-7901, MCF-7, and BEL-7404 with IC50 range from 7.26 to 47.41 μM.
Keywords: Davidia involucrata; Nyssaceae; triterpenoids; cytotoxicity Davidia involucrata; Nyssaceae; triterpenoids; cytotoxicity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Tan, Q.-W.; Ouyang, M.-A.; Gao, B. Three New Ring-A Modified Ursane Triterpenes from Davidia involucrata. Molecules 2014, 19, 4897-4906.

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