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Molecules 2014, 19(4), 4880-4896; doi:10.3390/molecules19044880
Article

Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds

1,* , 1 and 1,2
Received: 19 February 2014; in revised form: 9 March 2014 / Accepted: 10 March 2014 / Published: 17 April 2014
(This article belongs to the Section Medicinal Chemistry)
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Abstract: The aim of this study was to compare several methods for measurement of bovine serum albumin (BSA) modification by glycoxidation with reactive dicarbonyl compounds (methylglyoxal ‒ MGO and glyoxal ‒ GO), for studies of the kinetics of this process and to compare the effects of 19 selected compounds on BSA glycation by the aldehydes. The results confirm the higher reactivity of MGO with respect to GO and point to the usefulness of AGE, dityrosine and N′-formylkynurenine fluorescence for monitoring glycation and evaluation of protection against glycation. Different extent of protection against glycation induced by MGO and GO was found for many compounds, probably reflecting effects on various stages of the glycation process. Polyphenols (genistein, naringin and ellagic acid) were found to protect against aldehyde-induced glycation; 1-cyano-4-hydroxycinnamic acid was also an effective protector.
Keywords: glycation; kinetics; methylglyoxal; glyoxal; antioxidants glycation; kinetics; methylglyoxal; glyoxal; antioxidants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Sadowska-Bartosz, I.; Galiniak, S.; Bartosz, G. Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds. Molecules 2014, 19, 4880-4896.

AMA Style

Sadowska-Bartosz I, Galiniak S, Bartosz G. Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds. Molecules. 2014; 19(4):4880-4896.

Chicago/Turabian Style

Sadowska-Bartosz, Izabela; Galiniak, Sabina; Bartosz, Grzegorz. 2014. "Kinetics of Glycoxidation of Bovine Serum Albumin by Methylglyoxal and Glyoxal and its Prevention by Various Compounds." Molecules 19, no. 4: 4880-4896.



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