Abstract: Three new germacrane sesquiterpenes and a new m-menthane monoterpene were isolated together with four known compounds from the pericarp of Illicium lanceolatum, an adulterant to star anise (Illicium verum). All compounds were isolated from Illicium plants for the first time. The absolute stereochemistry of all germacranes and m-menthane was established by a combination of NMR and the modified Mosher’s ester method. The biological activity was evaluated on SH-SY5Y neuroblastoma cell line. (1S,5R,7R)-1,5-Dihydroxygermacra-4(15),10(14),11(12)-triene (at 62.5 µM) and (1R,5R,7R)-1,5-dihydroxygermacra-4(15),10(14),11(12)-triene (at 15.6 µM) promoted the proliferation of SH-SY5Y by 36.2% and 45.8%, respectively, after 48 h incubation, indicating potential neurotrophic activity.
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Zhao, M.; Zhang, X.; Wang, Y.; Huang, M.; Duan, J.-A.; Gödecke, T.; Szymulanska-Ramamurthy, K.M.; Yin, Z.; Che, C.-T. Germacranes and m-Menthane from Illicium lanceolatum. Molecules 2014, 19, 4326-4337.
Zhao M, Zhang X, Wang Y, Huang M, Duan J-A, Gödecke T, Szymulanska-Ramamurthy KM, Yin Z, Che C-T. Germacranes and m-Menthane from Illicium lanceolatum. Molecules. 2014; 19(4):4326-4337.
Zhao, Ming; Zhang, Xianming; Wang, Yan; Huang, Min; Duan, Jin-Ao; Gödecke, Tanja; Szymulanska-Ramamurthy, Karina M.; Yin, Zhiqi; Che, Chun-Tao. 2014. "Germacranes and m-Menthane from Illicium lanceolatum." Molecules 19, no. 4: 4326-4337.