Next Article in Journal
Germacranes and m-Menthane from Illicium lanceolatum
Previous Article in Journal
Bioactive 30-Noroleanane Triterpenes from the Pericarps of Akebia trifoliata
Article Menu

Export Article

Open AccessArticle
Molecules 2014, 19(4), 4313-4325; doi:10.3390/molecules19044313

Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand

Laboratory for Medicinal Chemistry, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium
Department of Pharmacology, University of North Carolina, School of Medicine, Chapel Hill, NC 27599-7365, USA
Author to whom correspondence should be addressed.
Received: 24 February 2014 / Revised: 28 March 2014 / Accepted: 31 March 2014 / Published: 4 April 2014
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [306 KB, uploaded 18 June 2014]   |  


In this study we report the synthesis of C5/C6-fused uridine phosphonates that are structurally related to earlier reported allosteric P2Y2 receptor ligands. A silyl-Hilbert-Johnson reaction of six quinazoline-2,4-(1H,3H)-dione-like base moieties with a suitable ribofuranosephosphonate afforded the desired analogues after full deprotection. In contrast to the parent 5-(4-fluoropheny)uridine phosphonate, the present extended-base uridine phosphonates essentially failed to modulate the P2Y2 receptor. View Full-Text
Keywords: nucleoside phosphonates; extended uridine; P2Y2 receptor nucleoside phosphonates; extended uridine; P2Y2 receptor

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Song, L.; Risseeuw, M.D.P.; Karalic, I.; Barrett, M.O.; Brown, K.A.; Harden, T.K.; Van Calenbergh, S. Synthesis of Extended Uridine Phosphonates Derived from an Allosteric P2Y2 Receptor Ligand. Molecules 2014, 19, 4313-4325.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top