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Molecules 2014, 19(4), 4338-4354; doi:10.3390/molecules19044338
Article

Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity

1,2,* , 3, 4, 5,6, 1,2, 6 and 1,2
1 Department of Chemistry and Biochemistry, Faculty of Agronomy, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic 2 Central European Institute of Technology, Brno University of Technology, Technicka 3058/10, CZ-616 00 Brno, Czech Republic 3 Centre of the Region Hana for Biotechnological and Agricultural Research, Faculty of Science, Palacky University & Institute of Experimental Botany, Academy of Sciences of Czech Republic, Slechtitelu 11, CZ-783 71 Olomouc, Czech Republic 4 Environmental Inorganic Chemistry, Department of Chemical and Biological Engineering, Chalmers University of Technology, SE-412 96 Göteborg, Sweden 5 Faculty of Military Health Sciences, University of Defence, Trebesska 1575, CZ-50001 Hradec Kralove, Czech Republic 6 Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, CZ-50005 Hradec Kralove, Czech Republic
* Author to whom correspondence should be addressed.
Received: 19 December 2013 / Revised: 31 March 2014 / Accepted: 1 April 2014 / Published: 8 April 2014
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Abstract

The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L1)](ttcH2)(ClO4)·EtOH·H2O (1), where L1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
Keywords: trithiocyanuric acid; trimercaptotriazine; crystal structure; complexes; acetylcholinesterase activity; Schiff base trithiocyanuric acid; trimercaptotriazine; crystal structure; complexes; acetylcholinesterase activity; Schiff base
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kopel, P.; Dolezal, K.; Langer, V.; Jun, D.; Adam, V.; Kuca, K.; Kizek, R. Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity. Molecules 2014, 19, 4338-4354.

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