Abstract: The complexes of Fe(II), Mn(II) and Ni(II) with a combination of a Schiff base, nitrogen-donor ligand or macrocyclic ligand and trithiocyanuric acid (ttcH3) were prepared and characterized by elemental analysis and spectroscopies. Crystal and molecular structures of the iron complex of composition [Fe(L1)](ttcH2)(ClO4)·EtOH·H2O (1), where L1 is Schiff base derived from tris(2-aminoethyl)amine and 2-pyridinecarboxaldehyde, were solved. It was found that the Schiff base is coordinated to the central iron atom by six nitrogens forming deformed octahedral arrangement, whereas trithiocyanurate(1-) anion, perchlorate and solvent molecules are not coordinated. The X-ray structure of the Schiff base sodium salt is also presented and compared with the iron complex. The anticholinesterase activity of the complexes was also studied.
Keywords: trithiocyanuric acid; trimercaptotriazine; crystal structure; complexes; acetylcholinesterase activity; Schiff base
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Kopel, P.; Dolezal, K.; Langer, V.; Jun, D.; Adam, V.; Kuca, K.; Kizek, R. Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity. Molecules 2014, 19, 4338-4354.
Kopel P, Dolezal K, Langer V, Jun D, Adam V, Kuca K, Kizek R. Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity. Molecules. 2014; 19(4):4338-4354.
Kopel, Pavel; Dolezal, Karel; Langer, Vratislav; Jun, Daniel; Adam, Vojtech; Kuca, Kamil; Kizek, Rene. 2014. "Trithiocyanurate Complexes of Iron, Manganese and Nickel and Their Anticholinesterase Activity." Molecules 19, no. 4: 4338-4354.