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Molecules 2014, 19(4), 3926-3939; doi:10.3390/molecules19043926
Article

Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice

1, 2, 3 and 4,*
Received: 9 February 2014 / Revised: 3 March 2014 / Accepted: 17 March 2014 / Published: 31 March 2014
(This article belongs to the Section Metabolites)
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Abstract

Angelica sinensis (AS) is a well-known medicinal herb and food material with antioxidative and multifunctional pharmacological activities. However, we lack evidence of the effect of AS on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effect of AS on ergogenic and anti-fatigue functions after physiological challenge. Male ICR strain mice were randomly assigned to four groups (n = 10 per group) for treatment: (1) sedentary control and vehicle treatment (vehicle control); (2) exercise training with vehicle treatment (exercise control); (3) exercise training with AS treatment at 0.41 g/kg/day (Ex-AS1); and (4) 2.05 g/kg/day (Ex-AS5); both the vehicle and AS were orally administered for 6 weeks. Exercise performance and anti-fatigue function were evaluated by forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, and creatine kinase (CK) after a 15-min swimming exercise. Trend analysis revealed that AS treatments significantly increased endurance swimming time and blood glucose level, and decreased serum lactate, ammonia and CK levels. Liver and muscle glycogen contents were higher for Ex-AS1 and Ex-AS5 groups than the exercise control. Therefore, AS supplementation improved exercise performance and had anti-fatigue properties in mice and may be an effective ergogenic aid in exercise training.
Keywords: Dong Quai; exhaustion; lactate; glycogen; exercise training Dong Quai; exhaustion; lactate; glycogen; exercise training
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Yeh, T.-S.; Huang, C.-C.; Chuang, H.-L.; Hsu, M.-C. Angelica sinensis Improves Exercise Performance and Protects against Physical Fatigue in Trained Mice. Molecules 2014, 19, 3926-3939.

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