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Molecules 2014, 19(4), 3940-3954; doi:10.3390/molecules19043940

Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function

, , , , ,  and *
KM-Based Herbal Drug Development Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Korea These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 8 January 2014 / Revised: 24 March 2014 / Accepted: 25 March 2014 / Published: 1 April 2014
(This article belongs to the Section Metabolites)
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The stem of Acer tegmentosum has been widely used in Korea for the treatment of hepatic disorders. In this study, we investigated the bone protective effect of water extract of the stem of Acer tegmentosum (WEAT). We found that WEAT inhibits osteoclast differentiation induced by receptor activator of nuclear factor-κB ligand (RANKL), an essential cytokine for osteoclast differentiation. In osteoclast precursor cells, WEAT inhibited RANKL-induced activation of JNK, NF-κB, and cAMP response element-binding protein, leading to suppression of the induction of c-Fos and nuclear factor of activated T cells cytoplasmic 1, key transcription factors for osteoclast differentiation. In addition, WEAT inhibited bone resorbing activity of mature osteoclasts. Furthermore, the oral administration of WEAT reduced RANKL-induced bone resorption and trabecular bone loss in mice. Taken together, our study demonstrates that WEAT possesses a protective effect on bone destruction by inhibiting osteoclast differentiation and function.
Keywords: Acer tegmentosum; osteoclast; bone; RANKL Acer tegmentosum; osteoclast; bone; RANKL
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Ha, H.; Shim, K.-S.; Kim, T.; An, H.; Lee, C.-J.; Lee, K.J.; Ma, J.Y. Water Extract of Acer tegmentosum Reduces Bone Destruction by Inhibiting Osteoclast Differentiation and Function. Molecules 2014, 19, 3940-3954.

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