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Molecules 2014, 19(4), 3909-3925; doi:10.3390/molecules19043909
Article

Comparison of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides from Fresh and Dried Litchi Pulp

1,2, 2, 3, 2, 2,* , 1,2, 2 and 2
Received: 17 February 2014; in revised form: 20 March 2014 / Accepted: 21 March 2014 / Published: 31 March 2014
(This article belongs to the Section Metabolites)
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Abstract: Drying is commonly used for preservation and processing of litchi. However, its polysaccharide structure may be altered by the drying process, resulting in biological activity changes. Polysaccharides from fresh and dried litchi pulp (denoted as LPF and LPD, respectively) were isolated, investigated by GC-MS, GPC and UV/IR spectrum analysis and their antitumor and immunomodulatory activities were evaluated in vitro. LPD, the molecular weight of which was lower than that of LPF, contained more protein, uronic acid, arabinose, galactose and xylose. Compared with LPF, LPD exhibited a higher inhibitory effect on the proliferation of HepG2, Hela and A549 cells from 50–750 μg/mL. LPD was also a better stimulator of spleen lymphocyte proliferation, NK cells cytotoxicity and macrophage phagocytosis from 50–400 μg/mL. In summary, drying could change the physicochemical properties and enhance the bioactivity of polysaccharides from litchi pulp. This finding is supported by the fact that dried litchi pulps are used in Traditional Chinese Medicine.
Keywords: litchi; drying; polysaccharides; anti-tumor activity; immunomodulatory activity litchi; drying; polysaccharides; anti-tumor activity; immunomodulatory activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Huang, F.; Zhang, R.; Yi, Y.; Tang, X.; Zhang, M.; Su, D.; Deng, Y.; Wei, Z. Comparison of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides from Fresh and Dried Litchi Pulp. Molecules 2014, 19, 3909-3925.

AMA Style

Huang F, Zhang R, Yi Y, Tang X, Zhang M, Su D, Deng Y, Wei Z. Comparison of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides from Fresh and Dried Litchi Pulp. Molecules. 2014; 19(4):3909-3925.

Chicago/Turabian Style

Huang, Fei; Zhang, Ruifen; Yi, Yang; Tang, Xiaojun; Zhang, Mingwei; Su, Dongxiao; Deng, Yuanyuan; Wei, Zhencheng. 2014. "Comparison of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides from Fresh and Dried Litchi Pulp." Molecules 19, no. 4: 3909-3925.



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