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Molecules 2014, 19(4), 3909-3925; doi:10.3390/molecules19043909

Comparison of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides from Fresh and Dried Litchi Pulp

Department of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Sericultural and Agri-food Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510610, China
College of Food Science & Engineering, Wuhan Polytechnic University, Wuhan 430023, China
Author to whom correspondence should be addressed.
Received: 17 February 2014 / Revised: 20 March 2014 / Accepted: 21 March 2014 / Published: 31 March 2014
(This article belongs to the Section Natural Products)
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Drying is commonly used for preservation and processing of litchi. However, its polysaccharide structure may be altered by the drying process, resulting in biological activity changes. Polysaccharides from fresh and dried litchi pulp (denoted as LPF and LPD, respectively) were isolated, investigated by GC-MS, GPC and UV/IR spectrum analysis and their antitumor and immunomodulatory activities were evaluated in vitro. LPD, the molecular weight of which was lower than that of LPF, contained more protein, uronic acid, arabinose, galactose and xylose. Compared with LPF, LPD exhibited a higher inhibitory effect on the proliferation of HepG2, Hela and A549 cells from 50–750 μg/mL. LPD was also a better stimulator of spleen lymphocyte proliferation, NK cells cytotoxicity and macrophage phagocytosis from 50–400 μg/mL. In summary, drying could change the physicochemical properties and enhance the bioactivity of polysaccharides from litchi pulp. This finding is supported by the fact that dried litchi pulps are used in Traditional Chinese Medicine. View Full-Text
Keywords: litchi; drying; polysaccharides; anti-tumor activity; immunomodulatory activity litchi; drying; polysaccharides; anti-tumor activity; immunomodulatory activity

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MDPI and ACS Style

Huang, F.; Zhang, R.; Yi, Y.; Tang, X.; Zhang, M.; Su, D.; Deng, Y.; Wei, Z. Comparison of Physicochemical Properties and Immunomodulatory Activity of Polysaccharides from Fresh and Dried Litchi Pulp. Molecules 2014, 19, 3909-3925.

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