Molecules 2014, 19(4), 3883-3897; doi:10.3390/molecules19043883
Article

Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species

1email, 1,2email, 1email, 3email and 1,* email
Received: 28 February 2014; in revised form: 17 March 2014 / Accepted: 21 March 2014 / Published: 28 March 2014
(This article belongs to the Section Metabolites)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Since our previous study revealed that several licorice phenolics have antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA), and suppressive effects on the oxacillin resistance of MRSA, we further investigated effectiveness of licorice constituents on vancomycin-resistant Enterococcus (VRE) bacteria, and purified 32 phenolic compounds. Two flavonoids among them were characterized structurally, and identified their structures as demethylglycyrol (31) and 5,7-di-O-methylluteone (32), respectively. Examination of antibacterial effects of licorice phenolics showed that 3-arylcoumarins such as licoarylcoumarin (9) and glycycoumarin (26), and 2-arylcoumarones such as gancaonin I (17), have moderate to potent antibacterial effects on the VRE strains used in this study.
Keywords: licorice; Glycyrrhiza uralensis; phenolics; flavonoid; 3-arylcoumarin; 2-arylcoumarone; VRE; antibacterial effect
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MDPI and ACS Style

Eerdunbayaer; Orabi, M.A.A.; Aoyama, H.; Kuroda, T.; Hatano, T. Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species. Molecules 2014, 19, 3883-3897.

AMA Style

Eerdunbayaer, Orabi MAA, Aoyama H, Kuroda T, Hatano T. Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species. Molecules. 2014; 19(4):3883-3897.

Chicago/Turabian Style

Eerdunbayaer; Orabi, Mohamed A.A.; Aoyama, Hiroe; Kuroda, Teruo; Hatano, Tsutomu. 2014. "Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species." Molecules 19, no. 4: 3883-3897.

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